# The Various Roles of PEDF in Cancer

## TL;DR

This review explores how PEDF, a versatile protein, can both prevent and promote cancer through various molecular pathways.

## Contribution

The paper provides a comprehensive overview of PEDF's dual roles in cancer progression and suppression.

## Key findings

- PEDF exhibits anti-inflammatory, anti-angiogenic, and anti-tumour properties.
- PEDF can enhance tumour response but also show pro-cancerous effects under certain conditions.
- Metastatic and metabolic biomarkers are key to understanding PEDF's functional activity.

## Abstract

Pigment epithelium-derived factor (PEDF) is a versatile protein with potent effects against various cancers. It hinders cancer initiation and spread. This review highlights some of the molecular pathways involved in PEDF’s anticancer properties.

Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF’s functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.