Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

TL;DR

This paper revisits the hypothesis that abnormal 3D genome structure is linked to cancer development, supported by recent studies confirming the importance of genome architecture in oncogenesis.

Contribution

It provides a detailed discussion and further insights into the hypothesis connecting abnormal chromatin configuration with cancer, building on past and recent research.

Findings

Recent studies support the role of 3D genome structure in cancer

The original hypothesis from 30 years ago is reinforced

Further insights into chromatin configuration and oncogenesis are discussed

Abstract

More than 30 years ago, we published a paper entitled as abnormal chromatin configuration and oncogenesis, which proposed the first hypothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis is presented.