# Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

## TL;DR

This paper revisits the hypothesis that abnormal 3D genome structure is linked to cancer development, supported by recent studies confirming the importance of genome architecture in oncogenesis.

## Contribution

It provides a detailed discussion and further insights into the hypothesis connecting abnormal chromatin configuration with cancer, building on past and recent research.

## Key findings

- Recent studies support the role of 3D genome structure in cancer
- The original hypothesis from 30 years ago is reinforced
- Further insights into chromatin configuration and oncogenesis are discussed

## Abstract

More than 30 years ago, we published a paper entitled as abnormal chromatin configuration and oncogenesis, which proposed the first hypothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis is presented.

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Source: https://tomesphere.com/paper/1901.04432