Cyclization of Short DNA Fragments
Pui-Man Lam, Yi Zhen
TL;DR
This paper introduces a model for short DNA flexibility, showing that shorter DNA is more flexible due to increased fluctuations, and aligns well with experimental J-factor data.
Contribution
It proposes an effective persistence length for short DNA based on free energy, improving the understanding of DNA flexibility at short lengths.
Findings
Effective persistence length decreases with shorter DNA.
Calculated J-factor matches experimental data.
Short DNA exhibits enhanced fluctuations and flexibility.
Abstract
From the per unit length free energy for DNA under tension, we have calculated an effective contour length dependent persistence length for short DNA. This effective persistence length results from the enhanced fluctuations in short DNA. It decreases for shorter DNA, making shorter DNA more flexible. The results of the J-factor calculated using this effective persistence length are in good agreement with experimental data.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.