# Cyclization of Short DNA Fragments

## TL;DR

This paper introduces a model for short DNA flexibility, showing that shorter DNA is more flexible due to increased fluctuations, and aligns well with experimental J-factor data.

## Contribution

It proposes an effective persistence length for short DNA based on free energy, improving the understanding of DNA flexibility at short lengths.

## Key findings

- Effective persistence length decreases with shorter DNA.
- Calculated J-factor matches experimental data.
- Short DNA exhibits enhanced fluctuations and flexibility.

## Abstract

From the per unit length free energy for DNA under tension, we have calculated an effective contour length dependent persistence length for short DNA. This effective persistence length results from the enhanced fluctuations in short DNA. It decreases for shorter DNA, making shorter DNA more flexible. The results of the J-factor calculated using this effective persistence length are in good agreement with experimental data.

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Source: https://tomesphere.com/paper/1705.02273