Long-range correlation in the whole human genome

TL;DR

This study analyzes the human genome's structure, revealing consistent long-range correlations across chromosomes and suggesting a multifractal, evolution-driven mechanism possibly governed by an expansion-modification dynamical system.

Contribution

It provides the first comprehensive analysis of mutual information across all human chromosomes, uncovering a universal correlation pattern and proposing a novel evolutionary mechanism.

Findings

Consistent long-range correlations across all chromosomes.

Detection of multifractal correlation patterns.

Implication of an expansion-modification dynamical system in genome evolution.

Abstract

We calculate the mutual information function for each of the 24 chromosomes in the human genome. The same correlation pattern is observed regardless the individual functional features of each chromosome. Moreover, correlations of different scale length are detected depicting a multifractal scenario. This fact suggest a unique mechanism of structural evolution. We propose that such a mechanism could be an expansion-modification dynamical system.