Temporal structure in neuronal activity during working memory in Macaque parietal cortex

TL;DR

This study reveals that gamma-band activity in macaque parietal cortex encodes working memory and movement plans, with LFP signals showing potential for neural prosthesis control due to their rich temporal structure.

Contribution

It demonstrates that LFP activity contains detailed movement-related information during working memory, providing insights for neural prosthesis development.

Findings

Elevated gamma-band power during memory period

LFP and SU activity coherence in gamma band

Organized LFP activity in 15-25 Hz related to movement

Abstract

A number of cortical structures are reported to have elevated single unit firing rates sustained throughout the memory period of a working memory task. How the nervous system forms and maintains these memories is unknown but reverberating neuronal network activity is thought to be important. We studied the temporal structure of single unit (SU) activity and simultaneously recorded local field potential (LFP) activity from area LIP in the inferior parietal lobe of two awake macaques during a memory-saccade task. Using multitaper techniques for spectral analysis, which play an important role in obtaining the present results, we find elevations in spectral power in a 50--90 Hz (gamma) frequency band during the memory period in both SU and LFP activity. The activity is tuned to the direction of the saccade providing evidence for temporal structure that codes for movement plans during working memory. We also find SU and LFP activity are coherent during the memory period in the 50--90 Hz gamma band and no consistent relation is present during simple fixation. Finally, we find organized LFP activity in a 15--25 Hz frequency band that may be related to movement execution and preparatory aspects of the task. Neuronal activity could be used to control a neural prosthesis but SU activity can be hard to isolate with cortical implants. As the LFP is easier to acquire than SU activity, our finding of rich temporal structure in LFP activity related to movement planning and execution may accelerate the development of this medical application.