Renormalization of Chiral Couplings in Tilted Bilayer Membranes

TL;DR

This paper investigates how chiral molecules influence the shape of lipid bilayer membranes, revealing that thermal fluctuations diminish membrane chirality at large scales and developing a perturbative method to analyze these effects.

Contribution

It introduces a continuum elasticity model incorporating thermal fluctuations and chirality, and demonstrates how fluctuations reduce membrane chirality at macroscopic scales.

Findings

Thermal fluctuations effectively reduce membrane chirality at large scales.

Developed a perturbative calculation scheme for membrane fluctuations.

Derived anomalous scaling relations for membrane structures.

Abstract

We study the effects of chiral constituent molecules on the macroscopic shapes attained by lipid bilayer membranes. Such fluid membranes are beautiful examples of statistical ensembles of random shapes, sometimes coupled to in-plane order. We analyze them with methods of continuum elasticity theory, generalizing the well-known Canham-Helfrich model, and in particular incorporate the effects of thermal fluctuations. The condition that coordinate choice be immaterial greatly constrains the possible forms of the statistical weights in these systems, leading to very few independent couplings and hence physically simple models. Thermal fluctuations effectively reduce the chirality of a membrane at long scales, leading to an anomalous scaling relation for the radius of bilayer tubules and helices as a function of chirality. En route to this conclusion we develop a perturbative calculation scheme, paying particular attention to the functional measure needed to describe fluctuations covariantly. %% [In the new version some TeX problems are fixed. This file was prepared with uufiles. To print it, clip out everything after the line of #'s below and put it in an executable file. If your mailer puts a spurious blank line at the end of part one, be sure to kill it. Then execute it to create a TeX file and four .eps files. The latter will be automatically included using epsf.tex. If this doesn't work, please contact the authors.]