Stripes of Partially Fluorinated Alkyl Chains: Dipolar Langmuir Monolayers

TL;DR

This study investigates stripe-like domain patterns in fluorinated lipid monolayers, revealing that dipole interactions stabilize these patterns and that their periodicity aligns with theoretical models, influenced by cholesterol addition.

Contribution

It provides the first detailed analysis of stripe formation in fluorinated lipid monolayers and quantifies the effects of dipolar interactions and cholesterol on domain periodicity.

Findings

Stripe periodicity ranges from 2 to 8 microns.

Dipolar interactions stabilize stripe patterns.

Cholesterol reduces domain periodicity.

Abstract

Stripe-like domains of Langmuir monolayers formed by surfactants with partially fluorinated lipid anchors (F-alkyl lipids) are observed at the gas-liquid phase coexistence. The average periodicity of the stripes, measured by fluorescence microscopy, is in the micrometer range, varying between 2 and 8 microns. The observed stripe-like patterns are stabilized due to dipole-dipole interactions between terminal -CF3 groups. These interactions are particularly strong as compared with non-fluorinated lipids due to the low dielectric constant of the surrounding media (air). These long-range dipolar interactions tend to elongate the domains, in contrast to the line tension that tends to minimize the length of the domain boundary. This behavior should be compared with that of the lipid monolayer having alkyl chains, and which form spherical micro-domains (bubbles) at the gas-liquid coexistence. The measured stripe periodicity agrees quantitatively with a theoretical model. Moreover, the reduction in line tension by adding traces (0.1 mol fraction) of cholesterol results, as expected, in a decrease in the domain periodicity.