Sum rules for free energy and frequency distribution of DNA dinucleotides

TL;DR

This paper introduces a three-parameter empirical formula for DNA dinucleotide free energy, derives sum rules, and assesses data reliability through theoretical and phenomenological analysis.

Contribution

It proposes a novel empirical formula based on the crystal basis model and derives sum rules to evaluate experimental data consistency.

Findings

Sum rules agree with experimental data

Data reliability varies across different samples

Theoretical relations link free energy and dimer distribution

Abstract

The large discrepancy between the values of the free energy for DNA dinucleotides (or dimers) measured by different teams has raised a yet unsettled debate. Here the free energy is fitted by a three parameter empiric formula derived in the framework of the crystal basis model of genetic code. Sum rules are derived and compared satisfactorily with the data. On the basis of theoretical and phenomenological arguments, a relation between the correlation functions of dimer distribution and the free energy is assumed. From consistency conditions, sum rules are derived. A check of these conditions with different samples of experimental data is performed, allowing us to argue on the reliability of the different sets of experimental data.