Pore Stability and Dynamics in Polymer Membranes

TL;DR

This paper investigates how membrane thickness influences pore stability and dynamics in polymer vesicles, revealing size-dependent behaviors with implications for drug delivery and filtration.

Contribution

It provides a detailed analysis of how membrane thickness affects pore behavior and stability in polymer vesicles, highlighting new insights into their dynamic properties.

Findings

Smaller d leads to large unstable pores and rapid reassembly.

Larger d results in long-lived nanometer-sized pores.

Membrane thickness critically influences pore stability and lifespan.

Abstract

Vesicles self-assembled from amphiphilic diblock copolymers exhibit a wide diversity of behavior upon electroporation, due to competitions between edge, surface and bending energies that drive the system, while different viscous dissipation mechanisms determine the timescales. These effects are manifestations of the varying membrane thickness d from what are essentially chemically identical molecules. For smaller d, we find large unstable pores and the resulting membrane fragments reassemble into vesicles within minutes. Vesicles with larger d form long-lived pores of nanometer dimension that could be potentially useful for sieving applications and drug delivery.