Hydrophobic interaction in the liquid phases of globular protein solutions: structure factor parameters

TL;DR

This paper introduces a model linking protein surface hydrophobicity to an effective interaction parameter, providing analytical insights into the structure factor relevant for static light scattering in globular protein solutions.

Contribution

It establishes a simple correspondence between hydrophobic surface topology and an effective Baxter-type adhesiveness parameter, enhancing understanding of protein interactions.

Findings

Effective protein-protein interaction parameter derived from surface hydrophobicity

Analytical interpretation of structure factor for light scattering

Framework applicable to globular protein solutions

Abstract

We develop a simple correspondence between hydrophobic surface topology of globular proteins and and an effective protein-protein adhesiveness parameter of the Baxter type. We discuss within this framework analytical interpretation of the structure factor governing static light scattering.