Solute Effects on the Helix-Coil Transition
Oded Farago, Philip Pincus
TL;DR
This paper investigates how solvent composition influences the helix-coil transition in polypeptides, showing that enhanced hydrogen-bonding ability reduces transition cooperativity without changing the transition temperature.
Contribution
It introduces a simple model demonstrating that solvent hydrogen-bonding ability affects transition cooperativity independently of transition temperature.
Findings
Improved hydrogen-bonding solvent reduces transition cooperativity.
Solvent effects can be distinct from melting temperature changes.
The model isolates specific solvent influences on helix-coil transition.
Abstract
We discuss the effects of the solvent composition on the helix-coil transition of a polypeptide chain. We use a simple model to demonstrate that improving the hydrogen-bonding ability of the solvent can make the transition less cooperative, without affecting the transition temperature. This effect is very different from other solvent effects which primarily influence the melting transition rather than the cooperativity.
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