# Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis

## TL;DR

This study reviews evidence showing that the pan-immune-inflammation value (PIV) can predict survival outcomes in colorectal cancer patients.

## Contribution

The study provides a meta-analysis confirming PIV as a novel prognostic biomarker for colorectal cancer.

## Key findings

- High baseline PIV is linked to worse overall and progression-free survival in colorectal cancer patients.
- An early increase in PIV after treatment is associated with reduced overall survival.
- There is significant heterogeneity in PIV cut-off values across studies.

## Abstract

The pan-immune-inflammation value (PIV) has been reported as a novel prognostic biomarker in multiple malignancies. The aim of this study is to investigate the prognostic value of the PIV in patients with colorectal cancer.

We comprehensively searched electronic databases including PubMed, Embase and Web of Science up to August 2022. The endpoints were survival outcomes. Hazard ratios (HRs) with 95% confidence intervals (CIs) for survival data were collected for analysis.

Six studies including 1879 participants were included. A significant heterogeneity in the PIV cut-off value among studies was observed. The combined results indicated that patients in the high baseline PIV group had a worse overall survival (HR=2.09; 95%CI: 1.67-2.61; P<0.0001; I2 = 7%) and progression-free survival (HR=1.82; 95%CI: 1.49-2.22; P<0.0001; I2 = 15%). In addition, early PIV increase after treatment initiation was significantly associated with decreased overall survival (HR=1.79; 95%CI: 1.13-2.93; P=0.01; I2 = 26%), and a trend toward poor progression-free survival (HR=2.00; 95%CI: 0.90-4.41; P=0.09; I2 = 70%).

Based on existing evidence, the PIV could act as a valuable prognostic index in patients with colorectal cancer. However, the heterogeneity in the PIV cut-off value among studies should be considered when interpreting these findings.