# Postoperative delirium in geriatric patients with hip fractures

**Authors:** Yang Chen, Shuai Liang, Huiwen Wu, Shihao Deng, Fangyuan Wang, Ciren Lunzhu, Jun Li

PMC · DOI: 10.3389/fnagi.2022.1068278 · Frontiers in Aging Neuroscience · 2022-12-22

## TL;DR

This review discusses postoperative delirium in elderly patients with hip fractures, focusing on risk factors, prevention, and treatment strategies.

## Contribution

The paper provides a narrative review of recent findings on postoperative delirium in geriatric hip fracture patients.

## Key findings

- Perioperative risk prediction and orthogeriatric care are effective in preventing delirium.
- Dexmedetomidine and multimodal analgesia may help manage delirium.
- Anesthesia technique choice does not significantly affect delirium incidence.

## Abstract

Postoperative delirium (POD) is a frequent complication in geriatric patients with hip fractures, which is linked to poorer functional recovery, longer hospital stays, and higher short-and long-term mortality. Patients with increased age, preoperative cognitive impairment, comorbidities, perioperative polypharmacy, and delayed surgery are more prone to develop POD after hip fracture surgery. In this narrative review, we outlined the latest findings on postoperative delirium in geriatric patients with hip fractures, focusing on its pathophysiology, diagnosis, prevention, and treatment. Perioperative risk prediction, avoidance of certain medications, and orthogeriatric comprehensive care are all examples of effective interventions. Choices of anesthesia technique may not be associated with a significant difference in the incidence of postoperative delirium in geriatric patients with hip fractures. There are few pharmaceutical measures available for POD treatment. Dexmedetomidine and multimodal analgesia may be effective for managing postoperative delirium, and adverse complications should be considered when using antipsychotics. In conclusion, perioperative risk intervention based on orthogeriatric comprehensive care is the most effective strategy for preventing postoperative delirium in geriatric patients with hip fractures.

## Linked entities

- **Chemicals:** Dexmedetomidine (PubChem CID 5311068)

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** pain (MESH:D010146), urinary tract infection (MESH:D014552), disturbance in attention and consciousness (MESH:D003244), dementia (MESH:D003704), heart failure (MESH:D006333), Postoperative infection (MESH:D013530), liver resection (MESH:D017093), hypernatremia (MESH:D006955), hip fracture (MESH:D006620), atherosclerosis (MESH:D050197), -matter hyperintensities (MESH:D056784), Delirium (MESH:D003693), personality alterations (MESH:D010554), malnutrition (MESH:D044342), inflammation (MESH:D007249), Diabetes (MESH:D003920), memory deficit (MESH:D008569), Osteoporotic hip fracture (MESH:D058866), systemic inflammatory response syndrome (MESH:D018746), Mental Disorders (MESH:D001523), Pneumonia (MESH:D011014), cerebral infarct (MESH:D002544), cancer (MESH:D009369), cerebral embolism (MESH:D020766), neurotoxicity (MESH:D020258), Metabolic abnormality (MESH:D008659), sepsis (MESH:D018805), inattention (MESH:D001308), bleeding (MESH:D006470), changes (MESH:D009402), fracture (MESH:D050723), neurodegenerative (MESH:D019636), osteoporosis (MESH:D010024), impaired vision or hearing (MESH:D054062), Comorbidity (MESH:D004194), cardiovascular and metabolic (MESH:D024821), mental problems (MESH:D008607), endothelial dysfunction (MESH:D014652), septic shock (MESH:D012772), Acute pain (MESH:D059787), POD (MESH:D000071257), postoperative complication (MESH:D011183), Hyponatremia (MESH:D007010), bradycardia (MESH:D001919), acute kidney injury (MESH:D058186), postoperative adverse events (MESH:D064420), Neuroinflammation (MESH:D000090862), CAM (MESH:D003221), sensorial deficits (MESH:D012678), impairment in attention and awareness (MESH:D058926), Trauma (MESH:D014947), critical (MESH:D016638), deep vein thrombosis (MESH:D020246), stoke (MESH:D000219), hip (MESH:D025981), coma (MESH:D003128), depression (MESH:D003866), Disturbance in attention (MESH:D001289), OBS (MESH:D019965), cholinergic (MESH:C535672)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC9813601/full.md

## References

154 references — full list in the complete paper: https://tomesphere.com/paper/PMC9813601/full.md

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Source: https://tomesphere.com/paper/PMC9813601