# Council of State and Territorial Epidemiologists/CDC Surveillance Case Definition for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 Infection — United States

**Authors:** Michael Melgar, Ellen H. Lee, Allison D. Miller, Sarah Lim, Catherine M. Brown, Anna R. Yousaf, Laura D. Zambrano, Ermias D. Belay, Shana Godfred-Cato, Joseph Y. Abrams, Matthew E. Oster, Angela P. Campbell

PMC · DOI: 10.15585/mmwr.rr7104a1 · 2022-12-16

## TL;DR

This paper outlines a case definition for MIS-C to help identify and distinguish it from other pediatric conditions linked to SARS-CoV-2.

## Contribution

It provides a standardized surveillance case definition for MIS-C in the U.S.

## Key findings

- The case definition was developed through literature review and retrospective analysis of reported cases.
- It aims to improve consistency in identifying MIS-C for public health surveillance.

## Abstract

regarding identification of MIS-C and its distinction from other pediatric conditions, a review of available literature comparing MIS-C phenotype with that of pediatric COVID-19 and other hyperinflammatory syndromes, and retrospective application of different criteria to data from MIS-C cases previously reported to CDC.

## Linked entities

- **Diseases:** MIS-C (MONDO:0100163), SARS-CoV-2 (MONDO:0100096)

## Full-text entities

- **Genes:** S (surface glycoprotein) [NCBI Gene 43740568] {aka spike glycoprotein}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, NPPB (natriuretic peptide B) [NCBI Gene 4879] {aka BNP, Iso-ANP}, N (nucleocapsid phosphoprotein) [NCBI Gene 43740575], CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** Shock (MESH:D012769), thrombotic (MESH:D013927), organ dysfunction (MESH:D009102), infectious disease (MESH:D003141), conjunctival injection (MESH:D003229), Kawasaki Disease (MESH:D009080), hyperinflammatory condition (MESH:D020763), ectasia (MESH:D004108), inflammation (MESH:D007249), gastrointestinal symptoms (MESH:D012817), Hematologic (MESH:D006402), acute respiratory distress syndrome (MESH:D012128), bacterial sepsis (MESH:D001424), thrombocytopenia (MESH:D013921), Chronic lung disease (MESH:D029424), respiratory, neurologic, (MESH:D012142), edema (MESH:D004487), Renal involvement (MESH:C565423), asthma (MESH:D001249), Children (MESH:D015362), vomiting (MESH:D014839), hyperinflammatory syndromes (MESH:D013577), COVID-19 (MESH:D000086382), dermatologic (MESH:D000168), diarrhea (MESH:D003967), Gastrointestinal (MESH:D005767), of the eyes (MESH:D005134), Respiratory (MESH:D012131), MIS-C (MESH:C000705967), infection (MESH:D007239), Obesity (MESH:D009765), Fever (MESH:D005334), coronary artery abnormalities (MESH:D003324), aneurysm (MESH:D000783), abdominal pain (MESH:D015746), headache (MESH:D006261), toxic shock syndrome (MESH:D012772), tickborne illness (MESH:D002908), lung disease (MESH:D008171), critically ill (MESH:D016638), coagulopathy (MESH:D001778), cardiovascular involvement (MESH:D002318), redness (MESH:C562718), renal (MESH:D006030), Death (MESH:D003643), Neurologic (MESH:D009461), hypotension (MESH:D007022), Mucocutaneous (MESH:D007897), rash (MESH:D005076), Cardiac (MESH:D006331), conjunctivitis (MESH:D003231), erythema (MESH:D004890)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC9762894