# An Overview of Anthropogenic Actions as Drivers for Emerging and Re-Emerging Zoonotic Diseases

**Authors:** Sina Salajegheh Tazerji, Roberto Nardini, Muhammad Safdar, Awad A. Shehata, Phelipe Magalhães Duarte

PMC · DOI: 10.3390/pathogens11111376 · 2022-11-18

## TL;DR

Human activities like deforestation and wildlife trafficking are increasing the risk of zoonotic diseases, which can spread from animals to humans.

## Contribution

The paper highlights how anthropogenic actions drive the emergence and re-emergence of zoonotic diseases and emphasizes the need for a One Health approach.

## Key findings

- Anthropogenic actions such as deforestation and wildlife trafficking increase contact with zoonotic pathogens.
- Emerging zoonotic diseases include viral, bacterial, parasitic, and fungal pathogens like Ebola and Lyme borreliosis.
- The One Health concept is proposed as a global strategy to mitigate zoonotic disease threats.

## Abstract

Population growth and industrialization have led to a race for greater food and supply productivity. As a result, the occupation and population of forest areas, contact with wildlife and their respective parasites and vectors, the trafficking and consumption of wildlife, the pollution of water sources, and the accumulation of waste occur more frequently. Concurrently, the agricultural and livestock production for human consumption has accelerated, often in a disorderly way, leading to the deforestation of areas that are essential for the planet’s climatic and ecological balance. The effects of human actions on other ecosystems such as the marine ecosystem cause equally serious damage, such as the pollution of this habitat, and the reduction of the supply of fish and other animals, causing the coastal population to move to the continent. The sum of these factors leads to an increase in the demands such as housing, basic sanitation, and medical assistance, making these populations underserved and vulnerable to the effects of global warming and to the emergence of emerging and re-emerging diseases. In this article, we discuss the anthropic actions such as climate changes, urbanization, deforestation, the trafficking and eating of wild animals, as well as unsustainable agricultural intensification which are drivers for emerging and re-emerging of zoonotic pathogens such as viral (Ebola virus, hantaviruses, Hendravirus, Nipah virus, rabies, and severe acute respiratory syndrome coronavirus disease-2), bacterial (leptospirosis, Lyme borreliosis, and tuberculosis), parasitic (leishmaniasis) and fungal pathogens, which pose a substantial threat to the global community. Finally, we shed light on the urgent demand for the implementation of the One Health concept as a collaborative global approach to raise awareness and educate people about the science behind and the battle against zoonotic pathogens to mitigate the threat for both humans and animals.

## Linked entities

- **Diseases:** leptospirosis (MONDO:0005825), Lyme borreliosis (MONDO:0019632), tuberculosis (MONDO:0018076), leishmaniasis (MONDO:0011989)

## Full-text entities

- **Genes:** fusion protein [NCBI Gene 920954], matrix protein [NCBI Gene 920953]
- **Diseases:** acrodermatitis chronica atrophicans (MESH:D000169), malaria (MESH:D008288), HCPS (MESH:D018778), neurological manifestations (MESH:D009461), Anxiety (MESH:D001007), EVD (MESH:D019142), Parasitic Diseases (MESH:D010272), NiV infection (MESH:D045464), Bat bites (MESH:D001733), MERS-CoV (MESH:D018352), Rabies (MESH:D011818), Zoonotic Diseases (MESH:D015047), bewilderment (MESH:D003221), encephalitis (MESH:D004660), deaths (MESH:D003643), Tick (MESH:D013985), HFRS (MESH:D006480), Tuberculosis (MESH:D014376), Leishmaniasis (MESH:D007896), chronic diseases (MESH:D002908), Fungal Diseases (MESH:D009181), diseases (MESH:D004194), hallucination (MESH:D006212), infection (MESH:D007239), respiratory (MESH:D012131), Viral Pathogens (MESH:D014777), bacterial zoonotic disease (MESH:D000086966), tick-borne disease (MESH:D017282), dermatophytosis (MESH:D014005), COVID-19 (MESH:D000086382), loss (MESH:D016388), Parkinson's disease (MESH:D010300), brucellosis (MESH:D002006), diabetes (MESH:D003920), Bacterial Diseases (MESH:D001424), non (MESH:C580335), malnutrition (MESH:D044342), Leptospirosis (MESH:D007922), Lyme (MESH:D008193), hemolytic bacteria (MESH:C000719206), drought (MESH:C536747), Erythe-ma migrans (MESH:D007815), ESBL (MESH:C579922), infectious diseases (MESH:D003141)
- **Chemicals:** vermin (-), N-phosphonomethylglycine (MESH:C010974), carbapenem (MESH:D015780), carbon (MESH:D002244)
- **Species:** Borreliella spielmanii (species) [taxon 88916], Ixodes ricinus (castor bean tick, species) [taxon 34613], Leptospira interrogans serovar Canicola (no rank) [taxon 211880], Mycobacterium tuberculosis (species) [taxon 1773], Tai Forest ebolavirus (no rank) [taxon 186541], Zaire ebolavirus (no rank) [taxon 186538], Sudan ebolavirus (no rank) [taxon 186540], Cervidae (deer, family) [taxon 9850], Ixodes scapularis (blacklegged tick, species) [taxon 6945], Borreliella afzelii (Borrellia group VS461, species) [taxon 29518], Sporothrix (genus) [taxon 29907], Candidozyma auris (species) [taxon 498019], Histoplasma (genus) [taxon 5036], Canis lupus familiaris (dog, subspecies) [taxon 9615], Borreliella burgdorferi (Lyme disease spirochete, species) [taxon 139], Mus musculus (house mouse, species) [taxon 10090], Ixodes persulcatus (taiga tick, species) [taxon 34615], Coccidioides (genus) [taxon 5500], Pteropus (genus) [taxon 9401], Bacillus sp. AT (species) [taxon 1196779], Felis catus (cat, species) [taxon 9685], Hendra virus [taxon 63330], Ebola virus [taxon 186536], Borreliella garinii (Borrelia genomic group 20047, species) [taxon 29519], Glycine max (soybean, species) [taxon 3847], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Leishmania infantum (species) [taxon 5671], Phoenix dactylifera (date palm, species) [taxon 42345], Bombali virus (no rank) [taxon 2010960], Henipavirus (genus) [taxon 260964], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], MLAV [taxon 2496529], NiV [taxon 121791], Ceratomyxa sp. VL (species) [taxon 364905], Reston ebolavirus (no rank) [taxon 186539], Marburgvirus [taxon 186537], Blastomyces (genus) [taxon 229219], Enterobacteriaceae (enterobacteria, family) [taxon 543], Sus scrofa (pig, species) [taxon 9823], Chiroptera (bats, order) [taxon 9397], Rattus norvegicus (brown rat, species) [taxon 10116], Leptospira sp. Pomona (species) [taxon 94063], Bundibugyo virus (no rank) [taxon 565995], Phlebotomus (subgenus) [taxon 44556], Borreliella mayonii (species) [taxon 1674146], Lutzomyia (subgenus) [taxon 252607], Borreliella bavariensis (species) [taxon 664662], Mephitidae (skunks, family) [taxon 119825], Pteropodidae (flying foxes, family) [taxon 9398], Procyon lotor (northern raccoon, species) [taxon 9654], Indopacetus pacificus (Longman's beaked whale, species) [taxon 221924], Equus caballus (domestic horse, species) [taxon 9796], Bos taurus (bovine, species) [taxon 9913], Candida albicans (species) [taxon 5476], Ebola virus (no rank) [taxon 1570291], Cuevavirus (genus) [taxon 1513236], Escherichia coli (E. coli, species) [taxon 562]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC9692567/full.md

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Source: https://tomesphere.com/paper/PMC9692567