# Research progress in membrane fusion-based hybrid exosomes for drug delivery systems

## TL;DR

This paper reviews hybrid exosomes made by fusing liposomes and exosomes, which could improve drug delivery with better targeting and biocompatibility.

## Contribution

The paper introduces membrane fusion-based hybrid exosomes as a novel drug delivery system combining the benefits of liposomes and exosomes.

## Key findings

- MFHEs offer high drug loading rates and targeted cellular uptake through surface modification.
- MFHEs have high biocompatibility and low immunogenicity, making them promising for drug delivery.
- The paper summarizes preparation methods and applications of MFHEs in disease treatment and research.

## Abstract

Liposomes are the earliest and most widely used nanoparticles for targeted drug delivery. Exosomes are nanosized membrane-bound particles and important mediators of intercellular communication. Combining liposomes and exosomes using various membrane fusion methods gives rise to a novel potential drug delivery system called membrane fusion-based hybrid exosomes (MFHE). These novel MFHEs not only exhibit potential advantageous features, such as high drug loading rate and targeted cellular uptake via surface modification, but are also endowed with high biocompatibility and low immunogenicity. Here, we provide an overview of MFHEs’ various preparation methods, characterization strategies, and their applications for disease treatment and scientific research.