Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy

TL;DR

This review discusses how combining multiple cancer treatments using nanoparticles can improve therapy effectiveness and reduce side effects.

Contribution

The paper provides a comprehensive overview of recent advances in nanoparticle-based co-delivery systems for cancer therapy.

Findings

Nanoparticle-based co-delivery systems enhance the synergistic effects of multiple drugs and genes.

Multidrug-loaded nanocarriers offer potential for improved cancer suppression with fewer side effects.

Designing co-delivery systems requires understanding drug ratios and cancer cell heterogeneity.

Abstract

Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of the encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy to fight cancer and the incorporation of co-delivery systems as a feasible treatment method has projected synergistic benefits and limited undesirable effects. Moreover, the development of co-delivery systems for maximum therapeutic impact necessitates better knowledge of the appropriate therapeutic agent ratio as well as the inherent heterogeneity of the cancer cells. Co-delivery systems can simplify clinical processes and increase patient quality of life, even though such systems are more difficult to prepare than single drug delivery systems. This review highlights the progress attained in the development and design of nano carrier-based co-delivery systems and discusses the limitations, challenges, and future perspectives in the design and fabrication of co-delivery systems.

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