# Cell membrane-camouflaged inorganic nanoparticles for cancer therapy

## TL;DR

This paper reviews how inorganic nanoparticles coated with cell membranes can improve cancer therapy by overcoming immune detection and enhancing drug delivery.

## Contribution

The paper provides a timely review of recent advances in cell membrane-camouflaged inorganic nanoparticles for cancer therapy.

## Key findings

- Cell membrane-coated nanoparticles inherit functional proteins and receptors for better tumor targeting.
- These nanoparticles show reduced immune detection and increased tumor accumulation.
- The review discusses both the potential and challenges of clinical translation for these nanoparticles.

## Abstract

Inorganic nanoparticles (INPs) have been paid great attention in the field of oncology in recent past years since they have enormous potential in drug delivery, gene delivery, photodynamic therapy (PDT), photothermal therapy (PTT), bio-imaging, driven motion, etc. To overcome the innate limitations of the conventional INPs, such as fast elimination by the immune system, low accumulation in tumor sites, and severe toxicity to the organism, great efforts have recently been made to modify naked INPs, facilitating their clinical application. Taking inspiration from nature, considerable researchers have exploited cell membrane-camouflaged INPs (CMCINPs) by coating various cell membranes onto INPs. CMCINPs naturally inherit the surface adhesive molecules, receptors, and functional proteins from the original cell membrane, making them versatile as the natural cells. In order to give a timely and representative review on this rapidly developing research subject, we highlighted recent advances in CMCINPs with superior unique merits of various INPs and natural cell membranes for cancer therapy applications. The opportunity and obstacles of CMCINPs for clinical translation were also discussed. The review is expected to assist researchers in better eliciting the effect of CMCINPs for the management of tumors and may catalyze breakthroughs in this area.