An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives
Leonardo Schirone, Maurizio Forte, Luca D’Ambrosio, Valentina Valenti, Daniele Vecchio, Sonia Schiavon, Giulia Spinosa, Gianmarco Sarto, Vincenzo Petrozza, Giacomo Frati, Sebastiano Sciarretta
TL;DR
This paper reviews the molecular causes of heart damage from heart attacks and explores new ways to protect the heart and reduce long-term damage.
Contribution
The paper provides a comprehensive review of recent advances in understanding molecular mechanisms of myocardial ischemic injury and potential therapies.
Findings
Molecular mechanisms like ROS overproduction and mitochondrial dysfunction contribute to myocardial ischemic injury.
New therapeutic interventions aim to boost cardioprotection and reduce cardiac remodeling.
Metabolic alterations and autophagy deregulation are key factors in post-ischemic cardiac remodeling.
Abstract
Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.
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Taxonomy
TopicsCardiac Ischemia and Reperfusion · Autophagy in Disease and Therapy · Mitochondrial Function and Pathology