Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy
Lupeng Zeng, Huaying Wang, Wanhua Shi, Lingfan Chen, Tingting Chen, Guanyu Chen, Wenshen Wang, Jianming Lan, Zhihong Huang, Jing Zhang, Jinghua Chen
TL;DR
This study explores using aloe-derived nanovesicles as a safe and effective way to deliver indocyanine green for cancer phototherapy.
Contribution
A novel aloe-derived nanocarrier is developed for drug delivery with high stability, low toxicity, and efficient melanoma targeting.
Findings
gADNVs showed high stability, antioxidant capacity, and no toxicity in vitro and in vivo.
ICG/gADNVs retained over 90% drug after 30 days and effectively inhibited melanoma growth.
gADNVs demonstrated skin penetrability, enabling noninvasive transdermal drug delivery.
Abstract
Cancer is one of the devastating diseases in the world. The development of nanocarrier provides a promising perspective for improving cancer therapeutic efficacy. However, the issues with potential toxicity, quantity production, and excessive costs limit their further applications in clinical practice. Herein, we proposed a nanocarrier obtained from aloe with stability and leak-proofness. We isolated nanovesicles from the gel and rind of aloe (gADNVs and rADNVs) with higher quality and yield by controlling the final centrifugation time within 20 min, and modulating the viscosity at 2.98 mPa S and 1.57 mPa S respectively. The gADNVs showed great structure and storage stability, antioxidant and antidetergent capacity. They could be efficiently taken up by melanoma cells, and with no toxicity in vitro or in vivo. Indocyanine green (ICG) loaded in gADNVs (ICG/gADNVs) showed great stability…
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Taxonomy
TopicsAdvancements in Transdermal Drug Delivery · Phytochemistry and biological activity of medicinal plants · Nanofluid Flow and Heat Transfer