# Key Global Actions for Mycotoxin Management in Wheat and Other Small Grains

**Authors:** John F. Leslie, Antonio Moretti, Ákos Mesterházy, Maarten Ameye, Kris Audenaert, Pawan K. Singh, Florence Richard-Forget, Sofía N. Chulze, Emerson M. Del Ponte, Alemayehu Chala, Paola Battilani, Antonio F. Logrieco

PMC · DOI: 10.3390/toxins13100725 · Toxins · 2021-10-14

## TL;DR

This paper outlines global strategies to manage mycotoxins in wheat and small grains, focusing on pre- and post-harvest interventions to ensure food safety.

## Contribution

The paper provides a comprehensive review and prioritization of global mycotoxin management strategies using the Nominal Group technique.

## Key findings

- Pre-harvest strategies include resistant host lines, fungicides, and cultural practices.
- Post-harvest methods like drying, storage, and cleaning are critical globally.
- The Nominal Group technique helped prioritize future steps for mycotoxin management.

## Abstract

Mycotoxins in small grains are a significant and long-standing problem. These contaminants may be produced by members of several fungal genera, including Alternaria, Aspergillus, Fusarium, Claviceps, and Penicillium. Interventions that limit contamination can be made both pre-harvest and post-harvest. Many problems and strategies to control them and the toxins they produce are similar regardless of the location at which they are employed, while others are more common in some areas than in others. Increased knowledge of host-plant resistance, better agronomic methods, improved fungicide management, and better storage strategies all have application on a global basis. We summarize the major pre- and post-harvest control strategies currently in use. In the area of pre-harvest, these include resistant host lines, fungicides and their application guided by epidemiological models, and multiple cultural practices. In the area of post-harvest, drying, storage, cleaning and sorting, and some end-product processes were the most important at the global level. We also employed the Nominal Group discussion technique to identify and prioritize potential steps forward and to reduce problems associated with human and animal consumption of these grains. Identifying existing and potentially novel mechanisms to effectively manage mycotoxin problems in these grains is essential to ensure the safety of humans and domesticated animals that consume these grains.

## Full-text entities

- **Genes:** CYP4F3 (cytochrome P450 family 4 subfamily F member 3) [NCBI Gene 4051] {aka CPF3, CYP4F, CYPIVF3, LTB4H}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** liver cancer (MESH:D006528), toxicity (MESH:D064420), food poisoning (MESH:D005517), death (MESH:D003643), emaciation (MESH:D004614), acute renal failure (MESH:D058186), immune system depression (MESH:D007154), plant disease (MESH:D010939), medical abnormalities (MESH:D004409), Black point of wheat (MESH:D021182), FHB disease (MESH:D060585), Mycotoxins (MESH:C000720973), renal nephropathy (MESH:D007674), miscarriage (MESH:D000022), vomiting (MESH:D014839), neural tube defects (MESH:D009436), dry gangrene (MESH:D005734), esophageal cancer (MESH:D004938), black point on (MESH:D007898), hallucinations (MESH:D006212), Infection (MESH:D007239), host disease (MESH:D004194), Ergot (MESH:D004881), pulmonary edema (MESH:D011654), NIV (MESH:C564985), acute tubular necrosis (MESH:D007683), Resistance to Disease (MESH:D060467), liver failure (MESH:D017093), teratogenic (MESH:C535542), carcinogens (MESH:D011230), diarrhea (MESH:D003967), fungal (MESH:D009181), stunting (MESH:D006130), liver and kidney failure (MESH:D051437), headaches (MESH:D006261), abdominal pain (MESH:D015746), black point disease (MESH:D055008), gain (MESH:D015430), visual scabby symptoms (MESH:D014786), estrogenic (MESH:D056828), Toxins (MESH:D065766), 15 (MESH:D012559), fire (MESH:D000092422), FHB (MESH:D006258)
- **Chemicals:** starch (MESH:D013213), carbendazim (MESH:C006698), Aflatoxins (MESH:D000348), O3 (MESH:D010126), strobilurins (MESH:D000073739), Ochratoxins (MESH:D009793), benzopyrenes (MESH:D001580), altenuene (MESH:C040005), chlorophyll (MESH:D002734), Ergot alkaloids (MESH:D004876), 3-ADON (MESH:C043247), fatty acids (MESH:D005227), sodium bisulfite (MESH:C009279), 17beta-estradiol (MESH:D004958), ochratoxin alpha (MESH:C000426), Trichothecenes (MESH:D014255), Fumonisins (MESH:D037341), Water (MESH:D014867), nivalenol (MESH:C038405), 15-ADON (MESH:C046760), metconazole (MESH:C000627121), Alkaloids (MESH:D000470), DON-3G (-), steroid hormones (MESH:D013256), sphingolipid (MESH:D013107), chlorine (MESH:D002713), ZEA (MESH:D015025), zearanol (MESH:D015029), Nitrogen (MESH:D009584), trichothecene (MESH:C000630165), Tebuconazole (MESH:C087114), Tenuazonic acid (MESH:D013720), sucrose (MESH:D013395), d-lysergic acid (MESH:D008238), azoxystrobin (MESH:C087670), alternariol monomethyl ether (MESH:C018206), Alternariol (MESH:C005197), enniatins (MESH:C100264), glucomannan (MESH:C022901), triazoles (MESH:D014230), sulfites (MESH:D013447), amide (MESH:D000577), tentoxin (MESH:C003384), perylene (MESH:D010569), CO2 (MESH:D002245), Graphene oxide (MESH:C000628730), DON (MESH:C007262), Steam (MESH:D013227), deoxynivalenol-3-glucoside (MESH:C542050), Aflatoxin B1 (MESH:D016604), clinoptilolite (MESH:C083175), phosphate (MESH:D010710), sugar (MESH:D000073893), phenylalanine (MESH:D010649), prothioconazole (MESH:C550005), OTA (MESH:C025589), bentonite (MESH:D001546), moniliformin (MESH:C008539), carbonate (MESH:D002254), lactone (MESH:D007783)
- **Species:** Sagamiharavirus PP (species) [taxon 2956385], Sorghum bicolor (broomcorn, species) [taxon 4558], Alternaria sect. Alternaria (section) [taxon 2499237], Fusarium acuminatum (species) [taxon 5515], C. purpurea [taxon 71299], Rattus norvegicus (brown rat, species) [taxon 10116], Fusarium proliferatum (species) [taxon 948311], Fusarium austroamericanum (species) [taxon 282268], Cucumis melo var. inodorus (casaba melon, varietas) [taxon 357961], Fusarium poae (species) [taxon 36050], Fusarium subglutinans (species) [taxon 42677], Medicago sativa (alfalfa, species) [taxon 3879], Sus scrofa (pig, species) [taxon 9823], Bacillus (genus) [taxon 55087], Rhodotorula (genus) [taxon 5533], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Fusarium sporotrichioides (species) [taxon 5514], Cryptococcus (genus) [taxon 79213], Brassica napus var. napus (annual rape, varietas) [taxon 138011], Fusarium tricinctum (species) [taxon 61284], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Meleagris gallopavo (common turkey, species) [taxon 9103], Limosilactobacillus reuteri (species) [taxon 1598], Alternaria alternata (species) [taxon 5599], Homo sapiens (human, species) [taxon 9606], Fusarium equiseti (species) [taxon 61235], Aspergillus flavus (species) [taxon 5059], Triticum turgidum subsp. durum (durum wheat, subspecies) [taxon 4567], Fusarium solani (species) [taxon 169388], Fusarium meridionale (species) [taxon 282269], Aspergillus westerdijkiae (species) [taxon 357447], Aspergillus steynii (species) [taxon 306088], Secale cereale (rye, species) [taxon 4550], Glycine max (soybean, species) [taxon 3847], Komagataella pastoris (species) [taxon 4922], Fusarium pseudograminearum (species) [taxon 101028], Fusarium cortaderiae (species) [taxon 281068], Fusarium verticillioides (species) [taxon 117187], Escherichia coli (E. coli, species) [taxon 562], P. verrucosum [taxon 764824], Fusarium oxysporum (species) [taxon 5507], Beta vulgaris subsp. vulgaris (field beet, subspecies) [taxon 3555], Pythium (genus) [taxon 4797], Alternaria infectoria (species) [taxon 45303], Fusarium asiaticum (species) [taxon 282267], Propionibacterium (genus) [taxon 1743], Alternaria mali (species) [taxon 167741], Trichoderma (genus) [taxon 5543], Penicillium verrucosum (species) [taxon 60171], Aspergillus (genus) [taxon 5052], Equus caballus (domestic horse, species) [taxon 9796], Bos taurus (bovine, species) [taxon 9913], Claviceps purpurea (ergot fungus, species) [taxon 5111], A. flavus [taxon 315677], Conioselinum tenuissimum (species) [taxon 110318], Arachis hypogaea (goober, species) [taxon 3818], Penicillium (genus) [taxon 5073], Ovis aries (domestic sheep, species) [taxon 9940], Fusarium avenaceum (species) [taxon 40199], Aspergillus ochraceus (species) [taxon 40380]

## Full text

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## References

438 references — full list in the complete paper: https://tomesphere.com/paper/PMC8541216/full.md

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Source: https://tomesphere.com/paper/PMC8541216