# Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment

## TL;DR

This paper reviews the current understanding of arteriovenous malformations, their causes, and treatment challenges.

## Contribution

The paper synthesizes preclinical and clinical findings to highlight gaps in AVM pathogenesis and treatment research.

## Key findings

- AVMs are present at birth and involve abnormal artery-vein connections.
- Current treatments are limited and AVMs can lead to severe health outcomes.
- Research gaps need to be addressed to develop effective therapies.

## Abstract

Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future.