# Novel insights in health-promoting properties of sweet cherries

**Authors:** Maria Felicia Faienza, Filomena Corbo, Alessia Carocci, Alessia Catalano, Maria Lisa Clodoveo, Maria Grano, David Q.-H. Wang, Gabriele D’Amato, Marilena Muraglia, Carlo Franchini, Giacomina Brunetti, Piero Portincasa

PMC · DOI: 10.1016/j.jff.2020.103945 · Journal of functional foods · 2021-08-19

## TL;DR

Sweet cherries contain bioactive compounds that may help prevent chronic diseases like diabetes and cancer due to their antioxidant properties.

## Contribution

This paper reviews the health benefits of sweet cherries and their bioactive compounds in preventing and modulating chronic diseases.

## Key findings

- Sweet cherries have bioactive compounds with antioxidant properties.
- They may help prevent and modulate chronic diseases like diabetes and cancer.
- More clinical studies are needed to confirm these health benefits.

## Abstract

Sweet cherry (Prunus avium L.) is one of the most popular and appreciated temperate fruit not only for its sensory and nutritional properties, but also for its content in bioactive compounds. Consumption of sweet cherries brings beneficial effects on to health, which include prevention and modulatory effects in several chronic diseases such as (diabetes mellitus, cancer, cardiovascular and other inflammatory diseases). The presence of natural polyphenolic compounds with high antioxidant potential might drive and partly explain such beneficial effects, but more translational and clinical studies should address this topic. Here, we review the health-promoting properties of cherries and their bioactive compounds against human diseases.

## Linked entities

- **Diseases:** diabetes mellitus (MONDO:0005015), cancer (MONDO:0004992)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, Tnf (tumor necrosis factor) [NCBI Gene 24835] {aka RATTNF, TNF-alpha, Tnfa}, TNFSF11 (TNF superfamily member 11) [NCBI Gene 8600] {aka CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B}, Ccnd1 (cyclin D1) [NCBI Gene 12443] {aka CycD1, Cyl-1, PRAD1, bcl-1, cD1}, Cdk1 (cyclin dependent kinase 1) [NCBI Gene 12534] {aka Cdc2, Cdc2a, p34<CDC2>}, COX1 (cytochrome c oxidase subunit I) [NCBI Gene 4512] {aka COI, MTCO1}, Ppara (peroxisome proliferator activated receptor alpha) [NCBI Gene 19013] {aka 4933429D07Rik, Nr1c1, PPAR-alpha, PPARalpha, Ppar}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11) [NCBI Gene 21943] {aka Ly109l, ODF, OPGL, RANKL, Trance}, COX2 (cytochrome c oxidase subunit II) [NCBI Gene 4513] {aka COII, MTCO2}, Lep (leptin) [NCBI Gene 16846] {aka ob, obese}, FCGR3A (Fc gamma receptor IIIa) [NCBI Gene 2214] {aka CD16-II, CD16A, FCG3, FCGR3, FCRIIIA, FcGRIIIA}, CCNB1 (cyclin B1) [NCBI Gene 891] {aka CCNB}, Ppara (peroxisome proliferator activated receptor alpha) [NCBI Gene 25747] {aka PPAR}
- **Diseases:** bone fractures (MESH:D050723), neurodegenerative diseases (MESH:D019636), diseases (MESH:D004194), metabolic syndrome (MESH:D024821), Liver steatosis (MESH:D005234), Sweet cherries (MESH:D016463), chilling injury (MESH:D023341), carcinogenic (MESH:D011230), arthritis (MESH:D001168), pain (MESH:D010146), I/R (MESH:D015427), gout (MESH:D006073), Obesity (MESH:D009765), water loss (MESH:D000069578), gastric adenocarcinoma (MESH:D013274), Inflammatory (MESH:D007249), cherries (MESH:D009081), bone resorption (MESH:D001862), hyperinsulinemia (MESH:D006946), vitamin E deficiency (MESH:D014811), chronic diseases (MESH:D002908), tissue injury (MESH:D017695), insulin resistance (MESH:D007333), liver damage (MESH:D056486), glucose intolerance (MESH:D018149), NAFLD (MESH:D065626), atherosclerotic plaque (MESH:D058226), cardiovascular and other inflammatory diseases (MESH:D002318), weight loss (MESH:D015431), diabetes (MESH:D003920), hyperglycemia (MESH:D006943), cancer (MESH:D009369), metabolic disorders (MESH:D008659), bone impairment (MESH:D001847), hyperlipidemia (MESH:D006949)
- **Chemicals:** LPS (MESH:D008070), Hydroxycinnamic acids (MESH:D003373), nitric oxide (MESH:D009569), Anthocyanidins (MESH:D000872), calcium (MESH:D002118), quercetin-3-rutinoside (MESH:D012431), TeA (MESH:D013720), sucrose (MESH:D013395), Minerals (MESH:D008903), flavonols (MESH:D044948), fiber (MESH:D004043), cholesterol (MESH:D002784), Cyanidin-3-glucoside (MESH:C462279), malondialdehyde (MESH:D008315), phosphorous (MESH:D010758), Melatonin (MESH:D008550), gibberellins (MESH:D005875), lipid (MESH:D008055), free radical (MESH:D005609), sugar (MESH:D000073893), urate (MESH:D014527), sodium (MESH:D012964), ROS (MESH:D017382), purine (MESH:C030985), CO2 (MESH:D002245), hydrocinnamic acid (MESH:C035253), flavan-3-ols (MESH:C404987), catechins (MESH:D002392), ice (MESH:D007053), metal (MESH:D008670), flavonoids (MESH:D005419), ascorbic acid (MESH:D001205), Phenols (MESH:D010636), glucose (MESH:D005947), Salt (MESH:D012492), alcohol (MESH:D000438), 8-oxo-deoxyguanosine (MESH:D000080242), ibuprofen (MESH:D007052), CaCl2 (MESH:D002122), cyanidin-3-glycoside (MESH:C000597824), allopurinol (MESH:D000493), vitamin E (MESH:D014810), p-coumaric acid (MESH:C495469), oxygen (MESH:D010100), fatty acid (MESH:D005227), phenolic acids (MESH:C017616), naproxen (MESH:D009288), chlorogenic acid (MESH:D002726), colchicine (MESH:D003078), sakuranetin (MESH:C099724), ferulic acid (MESH:C004999), potassium (MESH:D011188), triglyceride (MESH:D014280), UV-C (-), MeSA (MESH:C033069), steroid (MESH:D013256), Cyanidin-3-rutinoside (MESH:C428983), polyphenols (MESH:D059808), carbohydrates (MESH:D002241), sorbitol (MESH:D013012)
- **Species:** Prunus armeniaca (apricot, species) [taxon 36596], Candida albicans (species) [taxon 5476], Bos taurus (bovine, species) [taxon 9913], Prunus domestica (plum, species) [taxon 3758], Mus musculus (house mouse, species) [taxon 10090], Rattus norvegicus (brown rat, species) [taxon 10116], Prunus avium (gean, species) [taxon 42229], Alternaria alternata (species) [taxon 5599], Homo sapiens (human, species) [taxon 9606], Prunus persica (peach, species) [taxon 3760]
- **Cell lines:** pancreatic beta — Mesocricetus auratus (Golden hamster), Hamster pancreatic ductal adenocarcinoma, Cancer cell line (CVCL_5M15), SK-N-MC — Homo sapiens (Human), Askin tumor, Cancer cell line (CVCL_0530), Caco-2 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0025), RAW264 — Mus musculus (Mouse), Mouse leukemia, Cancer cell line (CVCL_0493), HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027), INS-1 832/13 — Rattus norvegicus (Rat), Rat insulinoma, Cancer cell line (CVCL_7226)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC8376227/full.md

## References

98 references — full list in the complete paper: https://tomesphere.com/paper/PMC8376227/full.md

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Source: https://tomesphere.com/paper/PMC8376227