# Illuminating Life’s Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules

**Authors:** Nicholas J. Green, Jianfeng Xu, John D. Sutherland

PMC · DOI: 10.1021/jacs.1c01839 · Journal of the American Chemical Society · 2021-04-21

## TL;DR

This paper explores how sunlight could have helped create the first building blocks of life through selective chemical reactions on early Earth.

## Contribution

The paper highlights the role of UV light in selectively forming biologically relevant molecules during prebiotic chemistry.

## Key findings

- UV light provides energy for the synthesis of proto-biomolecules from primordial building blocks.
- Light shows selectivity in favoring molecules relevant to modern biology.
- Photochemical processes may have been crucial in forming complex chemical systems on early Earth.

## Abstract

Solar radiation is the principal
source of energy available to
Earth and has unmatched potential for the synthesis of organic material
from primordial molecular building blocks. As well as providing the
energy for photochemical synthesis of (proto)biomolecules of interest
in origins of life-related research, light has also been found to
often provide remarkable selectivity in these processes, for molecules
that function in extant biology and against those that do not. As
such, light is heavily implicated as an environmental input on the
nascent Earth that was important for the emergence of complex yet
selective chemical systems underpinning life. Reactivity and selectivity
in photochemical prebiotic synthesis are discussed, as are their implications
for origins of life scenarios and their plausibility, and the future
directions of this research.

## Full-text entities

- **Genes:** HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1) [NCBI Gene 348980] {aka BCNG-1, BCNG1, DEE24, EIEE24, GEFSP10, HAC-2}, AOC2 (amine oxidase copper containing 2) [NCBI Gene 314] {aka DAO2, RAO, SSAO}
- **Diseases:** Norrish type II (MESH:D006938)
- **Species:** Dipturus trachyderma (ray, species) [taxon 255564]
- **Mutations:** cytidine 52 C, uracil 45 to thymine

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC8240947/full.md

## References

111 references — full list in the complete paper: https://tomesphere.com/paper/PMC8240947/full.md

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Source: https://tomesphere.com/paper/PMC8240947