# Advances in the Study of Metabolomics and Metabolites in Some Species Interactions

**Authors:** Rui Liu, Zheng-Xue Bao, Pei-Ji Zhao, Guo-Hong Li

PMC · DOI: 10.3390/molecules26113311 · Molecules · 2021-05-31

## TL;DR

This review discusses how metabolomics helps understand interactions between species and identifies new biologically active compounds.

## Contribution

The paper provides a comprehensive overview of recent advances and challenges in interspecies metabolomics.

## Key findings

- Metabolomics is a key tool for studying species interactions and host-pathogen defense mechanisms.
- Recent progress includes identifying new metabolites with biological activities through precision instruments.
- The review highlights current methods and future directions in interspecies metabolomics.

## Abstract

In the natural environment, interactions between species are a common natural phenomena. The mechanisms of interaction between different species are mainly studied using genomic, transcriptomic, proteomic, and metabolomic techniques. Metabolomics is a crucial part of system biology and is based on precision instrument analysis. In the last decade, the emerging field of metabolomics has received extensive attention. Metabolomics not only provides a qualitative and quantitative method for studying the mechanisms of interactions between different species, but also helps clarify the mechanisms of defense between the host and pathogen, and to explore new metabolites with various biological activities. This review focuses on the methods and progress of interspecies metabolomics. Additionally, the prospects and challenges of interspecies metabolomics are discussed.

## Full-text entities

- **Diseases:** infection (MESH:D007239), blast (MESH:D001753), toxicity (MESH:D064420), Fusarium (MESH:D060585), agricultural disease bacteria (MESH:C000719206), nematode infection (MESH:D009349), insect (MESH:C000719201)
- **Species:** Betula pubescens (downy birch, species) [taxon 38787], Trametes versicolor (turkey-tail fungus, species) [taxon 5325], Pieris rapae (cabbage white, species) [taxon 64459], Glycine max (soybean, species) [taxon 3847], Fusarium verticillioides (species) [taxon 117187], Fusarium oxysporum (species) [taxon 5507], Arabidopsis thaliana (mouse-ear cress, species) [taxon 3702], Acremonium [taxon 1036747], Serendipita indica (species) [taxon 65672], Didymosphaeria variabile (species) [taxon 1932322], Oryza sativa (Asian cultivated rice, species) [taxon 4530], Mycosarcoma maydis (corn smut, species) [taxon 5270], Cephalotaxus harringtonia (species) [taxon 58029], Medicago truncatula (barrel medic, species) [taxon 3880], Penicillium sp. (species) [taxon 5081], Zea mays (maize, species) [taxon 4577], Lolium perenne (perennial ryegrass, species) [taxon 4522], Achnatherum inebrians (species) [taxon 457187], Betula pubescens var. pumila (mountain birch, varietas) [taxon 251214], Ganoderma applanatum (artist's bracket, species) [taxon 29884], Epichloe festucae var. lolii (varietas) [taxon 73839], Sinorhizobium meliloti (species) [taxon 382], Homo sapiens (human, species) [taxon 9606], Rhizobium (genus) [taxon 379], P. variabile [taxon 502130], Epichloe (genus) [taxon 5112], Medicago sativa (alfalfa, species) [taxon 3879]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC8197931/full.md

## References

82 references — full list in the complete paper: https://tomesphere.com/paper/PMC8197931/full.md

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Source: https://tomesphere.com/paper/PMC8197931