# Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell Level

## TL;DR

This study uses single-cell RNA sequencing to explore placental changes in gestational diabetes, revealing new insights into its molecular causes.

## Contribution

The study provides a detailed single-cell transcriptomic atlas of the human placenta in gestational diabetes mellitus.

## Key findings

- A comprehensive cell atlas of the placenta was constructed, identifying cell subtypes and subtype-specific marker genes.
- Placental cellular functions and intercellular interactions were analyzed in the context of GDM.
- The findings offer new insights into the molecular mechanisms underlying GDM.

## Abstract

Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse pregnancy outcomes. Increasing evidence shows that placentation defects may play important roles in GDM. However, our understanding of the human placenta remains limited. In this study, we generated a comprehensive transcriptomic profile of cellular signatures and transcriptomes in the human placenta in GDM using single-cell RNA sequencing (scRNA-seq), constructed a comprehensive cell atlas, and identified cell subtypes and subtype-specific marker genes. In addition, we investigated the placental cellular function and intercellular interactions in GDM. These findings help to elucidate the molecular mechanisms of GDM, and may facilitate the development of new approaches to GDM treatment and prevention.