# Advances in Research of Adult Gliomas

## TL;DR

This review discusses recent progress in understanding adult brain tumors called gliomas and explores new models and treatments for better diagnosis and monitoring.

## Contribution

The paper provides a comprehensive summary of recent advances in glioma research using new models and techniques.

## Key findings

- In vitro and in vivo models have improved understanding of glioma development and progression.
- 3D organoids and organotypic slices are being used to study glioma heterogeneity and gene expression.
- In silico models and clinical trials are advancing early diagnosis and disease monitoring for gliomas.

## Abstract

Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact that they cannot be cured by current therapies, they represent one of the most devastating cancers. The present review summarises recent advances in our understanding of glioma development and progression by use of various in vitro and in vivo models, as well as more complex techniques including cultures of 3D organoids and organotypic slices. We discuss the progress that has been made in understanding glioma heterogeneity, alteration in gene expression and DNA methylation, as well as advances in various in silico models. Lastly current treatment options and future clinical trials, which aim to improve early diagnosis and disease monitoring, are also discussed.