# Club Cell Secreted Protein CC16: Potential Applications in Prognosis and Therapy for Pulmonary Diseases

## TL;DR

This review explores CC16, a protein linked to lung diseases, and its potential as a biomarker and treatment for conditions like COPD.

## Contribution

The paper provides a comprehensive review of CC16's role in pulmonary diseases and its potential clinical applications.

## Key findings

- CC16 has anti-inflammatory and anti-oxidative properties that may influence lung disease progression.
- CC16 levels are regulated by factors like age, obesity, and renal function, suggesting its potential as a biomarker.
- CC16 may serve as a promising therapeutic target for chronic obstructive pulmonary disease (COPD).

## Abstract

Club cell secretory protein (CC16) is encoded by the SCGB1A1 gene. It is also known as CC10, secretoglobin, or uteroglobin. CC16 is a 16 kDa homodimeric protein secreted primarily by the non-ciliated bronchial epithelial cells, which can be detected in the airways, circulation, sputum, nasal fluid, and urine. The biological activities of CC16 and its pathways have not been completely understood, but many studies suggest that CC16 has anti-inflammatory and anti-oxidative effects. The human CC16 gene is located on chromosome 11, p12-q13, where several regulatory genes of allergy and inflammation exist. Studies reveal that factors such as gender, age, obesity, renal function, diurnal variation, and exercise regulate CC16 levels in circulation. Current findings indicate CC16 not only may reflect the pathogenesis of pulmonary diseases, but also could serve as a potential biomarker in several lung diseases and a promising treatment for chronic obstructive pulmonary disease (COPD). In this review, we summarize our current understanding of CC16 in pulmonary diseases.