# Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

## TL;DR

This review explores the role of macrophages in osteosarcoma and their potential as targets for new immunotherapies.

## Contribution

The paper highlights macrophages as a novel therapeutic target in osteosarcoma immunotherapy.

## Key findings

- Macrophages are abundant in the osteosarcoma tumor microenvironment and influence tumor progression.
- Targeting macrophages offers a promising strategy for improving osteosarcoma treatment outcomes.
- Macrophages play a key role in the initiation and development of osteosarcoma.

## Abstract

Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies.