# Setting the standard: multidisciplinary hallmarks for structural, equitable and tracked antibiotic policy

**Authors:** Claas Kirchhelle, Paul Atkinson, Alex Broom, Komatra Chuengsatiansup, Jorge Pinto Ferreira, Nicolas Fortané, Isabel Frost, Christoph Gradmann, Stephen Hinchliffe, Steven J Hoffman, Javier Lezaun, Susan Nayiga, Kevin Outterson, Scott H Podolsky, Stephanie Raymond, Adam P Roberts, Andrew C Singer, Anthony D So, Luechai Sringernyuang, Elizabeth Tayler, Susan Rogers Van Katwyk, Clare I R Chandler

PMC · DOI: 10.1136/bmjgh-2020-003091 · BMJ Global Health · 2020-09-23

## TL;DR

This paper proposes three key characteristics for effective global antibiotic policies to address antimicrobial resistance and its complex challenges.

## Contribution

The paper introduces three novel hallmarks—Structural, Equitable, and Tracked—for designing and evaluating antibiotic policies.

## Key findings

- Current international antibiotic policy faces four central challenges: metrics, prioritisation, implementation, and inequality.
- The proposed hallmarks aim to improve antibiotic policy design and evaluation at local and international levels.

## Abstract

There is increasing concern globally about the enormity of the threats posed by antimicrobial resistance (AMR) to human, animal, plant and environmental health. A proliferation of international, national and institutional reports on the problems posed by AMR and the need for antibiotic stewardship have galvanised attention on the global stage. However, the AMR community increasingly laments a lack of action, often identified as an ‘implementation gap’. At a policy level, the design of internationally salient solutions that are able to address AMR’s interconnected biological and social (historical, political, economic and cultural) dimensions is not straightforward. This multidisciplinary paper responds by asking two basic questions: (A) Is a universal approach to AMR policy and antibiotic stewardship possible? (B) If yes, what hallmarks characterise ‘good’ antibiotic policy? Our multistage analysis revealed four central challenges facing current international antibiotic policy: metrics, prioritisation, implementation and inequality. In response to this diagnosis, we propose three hallmarks that can support robust international antibiotic policy. Emerging hallmarks for good antibiotic policies are: Structural, Equitable and Tracked. We describe these hallmarks and propose their consideration should aid the design and evaluation of international antibiotic policies with maximal benefit at both local and international scales.

## Full-text entities

- **Genes:** ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)) [NCBI Gene 84680] {aka ACS, PHACS}, PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1) [NCBI Gene 5366] {aka APR, NOXA}, NR0B2 (nuclear receptor subfamily 0 group B member 2) [NCBI Gene 8431] {aka SHP, SHP1}
- **Diseases:** malaria (MESH:D008288), HIV/AIDS (MESH:D015658), OIE (MESH:D000820), onchocerciasis (MESH:D009855), death (MESH:D003643), tuberculosis (MESH:D014376), scabies (MESH:D012532), stunting (MESH:D006130), gram-negative infections (MESH:D016905), Infection (MESH:D007239), polio (MESH:D011051), impetigo (MESH:D007169), bloodstream infections (MESH:D018805), COVID-19 (MESH:D000086382), drug-resistant infection (MESH:D000069279), bacterial pathogens (MESH:D001424), SET (MESH:D020914), WASH (MESH:D000069578), Antibiotic Resistance (MESH:D004761), AMR (MESH:D060467), infectious disease (MESH:D003141), lymphatic filariasis (MESH:D004605)
- **Species:** Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823], Staphylococcus aureus (species) [taxon 1280], Escherichia coli (E. coli, species) [taxon 562]
- **Cell lines:** CARB-X — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_2768)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC7513567/full.md

## References

162 references — full list in the complete paper: https://tomesphere.com/paper/PMC7513567/full.md

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Source: https://tomesphere.com/paper/PMC7513567