An Overview of Managements in Meningiomas

Lianhua Zhao; Wei Zhao; Yanwei Hou; Cuixia Wen; Jing Wang; Pei Wu; Zaiyu Guo

PMC · DOI:10.3389/fonc.2020.01523·August 21, 2020·90 cites

An Overview of Managements in Meningiomas

Lianhua Zhao, Wei Zhao, Yanwei Hou, Cuixia Wen, Jing Wang, Pei Wu, Zaiyu Guo

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TL;DR

This review discusses current and future treatment strategies for meningiomas, which are common brain tumors.

Contribution

The paper provides a comprehensive overview of treatment strategies and highlights ongoing research directions.

Findings

01

Surgery and radiotherapy remain the main treatments for meningiomas.

02

Systemic therapies like chemotherapy have not been proven effective in large data series.

03

Ongoing clinical trials are exploring new treatment options for meningiomas.

Abstract

Meningioma is the most frequent primary tumor of the central nervous system. Important advances have been achieved in the treatment of meningioma in recent decades. Although most meningiomas are benign and have a good prognosis after surgery, clinicians often face challenges when the morphology of the tumor is complicated or the tumor is close to vital brain structures. At present, the longstanding treatment strategies of meningioma are mainly surgery and radiotherapy. The effectiveness of systemic therapy, such as chemotherapy or targeted therapy, has not been confirmed by big data series, and some clinical trials are still in progress. In this review, we summarize current treatment strategies and future research directions for meningiomas.

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes23

KDR EGF NF2 TNF RET SST PTK2B MTOR IFNA2 POLR2A TXK KLF4 TRAF7 AR SMO AKT1 ESR1 VEGFA EGFR PDGFRB PIK3R1 MAPK1 RARA

Proteins23

Species2

Homo sapiens(human · species)herpes virus

Chemicals23

Diseases56

meningioma metastatic ependymoma III meningiomas died toxicity brain tissue or vascular injury cavernous sinus meningiomas cranial nerve injury brain edema III coagulation GTR vessel injuries intracranial hemorrhage necrosis vascular injury cerebral infarction WHO grade I meningioma II and III venous infarction ischemic necrosis vasospasm venous sinus PTE nerve injury occlusion of venous sinuses neurological deficit Tumor internal carotid artery branch embolism anterior skull base meningiomas infection ischemic complications central nervous system tumor Epilepsy seizure bleeding optic nerve radiation reaction brain tissue occlusion of blood vessels neurological complications postoperative infection cerebral hemorrhage Tuberculum sellae meningiomas brain tumor lesions gliomas pressure invasive tumors hemangioblastoma Cerebrospinal fluid leakage hemangioma intracranial mass calcification visual impairment embolization

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Taxonomy

TopicsMeningioma and schwannoma management · Neurofibromatosis and Schwannoma Cases · Head and Neck Surgical Oncology