# Recent applications of ring-rearrangement metathesis in organic synthesis

**Authors:** Sambasivarao Kotha, Milind Meshram, Priti Khedkar, Shaibal Banerjee, Deepak Deodhar

PMC · DOI: 10.3762/bjoc.11.199 · 2015-10-07

## TL;DR

This review discusses recent uses of ring-rearrangement metathesis in making complex organic molecules efficiently.

## Contribution

The novelty lies in summarizing recent advancements in ring-rearrangement metathesis for streamlined organic synthesis.

## Key findings

- RRM enables multi-bond formation in a single step, improving atom economy.
- The review highlights RRM's ability to synthesize complex frameworks not easily achieved by traditional methods.
- Applications from 2008–2014 demonstrate RRM's growing importance in organic synthesis.

## Abstract

Ring-rearrangement metathesis (RRM) involves multiple metathesis processes such as ring-opening metathesis (ROM)/ring-closing metathesis (RCM) in a one-pot operation to generate complex targets. RRM delivers complex frameworks that are difficult to assemble by conventional methods. The noteworthy point about this type of protocol is multi-bond formation and it is an atom economic process. In this review, we have covered literature that appeared during the last seven years (2008–2014).

## Full-text entities

- **Diseases:** cancer (MESH:D009369), RRM (MESH:D012303), sedative (MESH:C535788), hypotensive (MESH:D007022)
- **Chemicals:** Cu(OTf)2 (MESH:C012077), andrachcinidine (MESH:C585228), (+)-lepadin B (MESH:C414923), sodium hydride (MESH:C524957), aldol (MESH:C116609), saccharides (MESH:D002241), Cyclopentene (MESH:D003517), toluene (MESH:D014050), sulfonamide (MESH:D013449), dihydropyrans (MESH:C073813), Pd (MESH:D010165), Bicyclo[2.2.1]heptene (MESH:C116378), tetrabutylammonium iodide (MESH:C009405), diol (MESH:D011276), Phelligridin G (MESH:C507450), Cyclohexene (MESH:C052568), pyridine (MESH:C023666), vinyl acetate (MESH:C011566), phosphonate (MESH:D063065), 1,3-cyclohexadiene (MESH:C034005), chlorobenzene (MESH:C031294), indolizidine (MESH:D054836), methyl acrylate (MESH:C035956), aldehyde (MESH:D000447), 2-methoxyphenol (MESH:D006139), acetogenin (MESH:D054378), (+-)-porantheridine (MESH:C450779), sugar (MESH:D000073893), sultam (MESH:C016768), butenolide (MESH:C004511), lactone (MESH:D007783), pyrrolidine (MESH:C032519), alkene (MESH:D000475), ruthenium (MESH:D012428), c (MESH:D002244), titanium isopropoxide (MESH:C102815), C6H6 (MESH:D001554), allyl bromide (MESH:C050431), caribenol A (MESH:C555112), ethylene (MESH:C036216), (+-)-8-epihalosaline (MESH:C552161), pyran (MESH:D011714), (-)-isoschizogamine (MESH:C409122), schintrilactones A (MESH:C524149), anhydride (MESH:D000812), alkaloid (MESH:D000470), heterocyclic compounds (MESH:D006571), Ru-carbene (-), polycyclic compounds (MESH:D011083), ester (MESH:D004952), norbornene derivative (MESH:D009636), asteriscunolide D (MESH:C449600), THF (MESH:C018674), vinyl ether (MESH:C100195), decalin (MESH:C007229), nitrogen (MESH:D009584), n-BuLi (MESH:C434823), o-benzoquinones (MESH:D016227), isocyanides (MESH:D003486), DBU (MESH:C031033)
- **Species:** Homo sapiens (human, species) [taxon 9606], Phellinus igniarius (species) [taxon 40472]

## Figures

50 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4660990/full.md

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Source: https://tomesphere.com/paper/PMC4660990