# Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation

**Authors:** Ryosuke Kurokawa, Tomoki Seo, Bunpei Sato, Shin-ichi Hirano, Fumitake Sato

PMC · DOI: 10.1186/s13618-015-0034-2 · Medical Gas Research · 2015-10-26

## TL;DR

This study introduces safe and convenient methods for administering molecular hydrogen through drinking, injection, and inhalation.

## Contribution

The paper presents novel devices for safely delivering molecular hydrogen in clinical and research settings.

## Key findings

- Devices for H2 water drinking, saline infusion, and gas inhalation were developed.
- Changes in H2 concentration were analyzed for research utility.

## Abstract

Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these devices, the changes in H2 concentration were studied. Our experimental results should contribute to the advance of non-clinical and clinical research in H2 medicine.

## Linked entities

- **Chemicals:** molecular hydrogen (PubChem CID 783), H2 (PubChem CID 783)

## Full-text entities

- **Diseases:** inflammation (MESH:D007249)
- **Chemicals:** H2 water (-), N (MESH:D009584), Isotonic sodium chloride (MESH:D012965), Water (MESH:D014867), H2 (MESH:D006859), lipid (MESH:D008055), polyethylene (MESH:D020959), Glucose (MESH:D005947), aluminum (MESH:D000535), acrylic resin (MESH:D000180), calcium hydroxide (MESH:D002126), Sodium hydrogen carbonate (MESH:D017693)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC4620630/full.md

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4620630/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC4620630/full.md

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Source: https://tomesphere.com/paper/PMC4620630