# Live or Die: Choice Mechanisms in Stressed Cells

**Authors:** Francesco Cecconi, Laura Soucek, Dennis D. Taub, Elio Ziparo

PMC · DOI: 10.1155/2015/454863 · 2015-10-08

## Full-text entities

- **Genes:** CDKN1C (cyclin dependent kinase inhibitor 1C) [NCBI Gene 1028] {aka BWCR, BWS, KIP2, WBS, p57, p57Kip2}, Casp8 (caspase 8) [NCBI Gene 12370] {aka CASP-8, FLICE, MACH, Mch5}, Fadd (Fas associated via death domain) [NCBI Gene 14082] {aka Mort1/FADD}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)) [NCBI Gene 10257] {aka MOAT-B, MOATB, MRP4}, ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) [NCBI Gene 128] {aka ADH-3, ADHX, AMEDS, BMFS7, FALDH, FDH}, Sod1 (superoxide dismutase 1, soluble) [NCBI Gene 20655] {aka B430204E11Rik, Cu/Zn-SOD, CuZnSOD, Ipo-1, Ipo1, SODC}, Cflar (CASP8 and FADD-like apoptosis regulator) [NCBI Gene 12633] {aka 2310024N18Rik, A430105C05Rik, CLARP, Cash, Casper, FLAME}
- **Diseases:** ischemic brain injury (MESH:D001930), Amyotrophic Lateral Sclerosis (MESH:D000690), heart disease (MESH:D006331), Hepatotoxic Drugs (MESH:D000081015), stroke (MESH:D020521), motor neuron degeneration (MESH:D009410), myocardial infarction (MESH:D009203), Diabetic Nephropathy (MESH:D003928), cardiovascular diseases (MESH:D002318), Toxicity (MESH:D064420), degenerative diseases (MESH:D019636), Hypoxia (MESH:D000860), Cancer (MESH:D009369), Parkinson's Disease (MESH:D010300), myocardial pyroptosis (MESH:D009202), DILI (MESH:D056486), Hypoxic (MESH:D002534), Breast Cancer (MESH:D001943), Inflammatory (MESH:D007249), Hypertrophy (MESH:D006984), (MESH:D008107)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Geodia cydonium (species) [taxon 6047], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** G93A
- **Cell lines:** MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031), HEK-293 — Homo sapiens (Human), Transformed cell line (CVCL_0045), C2C12 — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0188), SH-SY5Y — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0019)

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Source: https://tomesphere.com/paper/PMC4609861