# Treatment of Sleep Disordered Breathing Liberates Obese Hypoxemic Patients from Oxygen

## TL;DR

Treating sleep disordered breathing in obese patients with low oxygen levels can significantly improve their daytime oxygen levels and reduce the need for supplemental oxygen.

## Contribution

This study shows that treating SDB in obese hypoxemic patients can lead to liberation from supplemental oxygen.

## Key findings

- 60% of patients adhered to PAP therapy, which improved daytime hypoxemia and hypercapnea.
- 56% of patients who adhered to PAP therapy were able to stop using supplemental oxygen.
- Adherence to PAP therapy, not baseline OSA severity, predicted liberation from supplemental oxygen.

## Abstract

Obese hypoxemic patients have a high prevalence of sleep disordered breathing (SDB). It is unclear to what extent treatment of SDB can improve daytime hypoxemia.

We performed a retrospective cohort study of obese hypoxemic individuals, all of whom underwent polysomnography, arterial blood gas analysis, and subsequent initiation of positive airway pressure (PAP) therapy for SDB. Patients were followed for one year for change in partial pressure of arterial oxygen and the need for supplemental oxygen.

One hundred and seventeen patients were treated with nocturnal PAP and had follow-up available. Adherence to PAP was satisfactory in 60%, and was associated with a significant improvement in daytime hypoxemia and hypercapnea; 56% of these patients were able to discontinue supplemental oxygen. Adherence to PAP therapy and the baseline severity of OSA predicted improvement in hypoxemia, but only adherence to PAP therapy predicted liberation from supplemental oxygen.

The identification and treatment of SDB in obese hypoxemic patients improves daytime hypoxemia. It is important to identify SDB in these patients, since supplemental oxygen can frequently be discontinued following treatment with PAP therapy.