# Resistance is not Futile: It Shapes Insecticide Discovery

**Authors:** Margaret C. Hardy

PMC · DOI: 10.3390/insects5010227 · Insects · 2014-01-23

## TL;DR

This paper discusses the importance of insecticides in pest control and highlights recent innovations to combat insecticide resistance.

## Contribution

The paper emphasizes the ongoing innovation in insecticide development to address resistance and support pest management.

## Key findings

- Insecticides remain essential for protecting agriculture and human health despite resistance challenges.
- Recent research focuses on developing new insecticides to combat resistance effectively.
- Innovations in insecticide development are crucial for biosecurity and food supply protection.

## Abstract

Conventional chemical control compounds used for the management of insect pests have been much maligned, but still serve a critical role in protecting people and agricultural products from insect pests, as well as conserving biodiversity by eradicating invasive species. Although biological control can be an effective option for area-wide management of established pests, chemical control methods are important for use in integrated pest management (IPM) programs, as well as in export treatments, eradicating recently arrived invasive species, and minimizing population explosions of vectors of human disease. Cogitated research and development programs have continued the innovation of insecticides, with a particular focus on combating insecticide resistance. Recent developments in the fields of human health, protecting the global food supply, and biosecurity will be highlighted.

## Full-text entities

- **Genes:** ACHE (acetylcholinesterase (Yt blood group)) [NCBI Gene 43] {aka ACEE, ARACHE, N-ACHE, YT}
- **Diseases:** Ross River Fever (MESH:D018354), infection (MESH:D007239), malaria (MESH:D008288), Neurotoxic insecticidal compounds (MESH:D005597), filariasis worm (MESH:D005368), toxicity (MESH:D064420), dengue fever (MESH:D003715), Eastern Equine Encephalitis (MESH:D020242), insect pests (MESH:C000719201), neurotoxic (MESH:D020258), elephantiasis (MESH:D004604)
- **Chemicals:** sodium (MESH:D012964), deltamethrin (MESH:C017180), methylhydroquinone (MESH:C062397), etofenprox (MESH:C076840), carbamates (MESH:D002219), IRAC (-), Pyrethroids (MESH:D011722), organochlorines (MESH:D006843), organophosphate (MESH:D010755), carbon (MESH:D002244), 3-methyl-4-nitrophenol (MESH:C008636), fenitrothion (MESH:D005278), DDT (MESH:D003634), phosphine (MESH:C044646)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Burkholderia (genus) [taxon 32008], Plasmodium vivax (malaria parasite P. vivax, species) [taxon 5855], Plasmodium falciparum (malaria parasite P. falciparum, species) [taxon 5833], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4592624/full.md

## References

69 references — full list in the complete paper: https://tomesphere.com/paper/PMC4592624/full.md

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Source: https://tomesphere.com/paper/PMC4592624