# Insulator Protein Helps Organize the Gaps in the Axon's Insulation

**Authors:** Richard Robinson

PMC · DOI: 10.1371/journal.pbio.1002259 · PLoS Biology · 2015-09-25

## TL;DR

A protein called P0 helps organize the gaps in nerve insulation, which is important for nerve signal transmission.

## Contribution

The study shows that P0 has a new role in organizing the nodes of Ranvier in addition to its known role in myelin sheath formation.

## Key findings

- P0 is important for organizing the nodes of Ranvier in peripheral nerves.
- The protein P0 has a dual role in nerve insulation and node organization.

## Abstract

The protein P0 has long been known to play a crucial role in holding together the myelin sheath that insulates peripheral nerves. A new study reveals that P0 is also important for organizing the nodes of Ranvier that occupy the gaps in the insulation. Read the Research Article.

## Linked entities

- **Proteins:** MPZ (myelin protein zero)

## Full-text entities

- **Genes:** Cntnap1 (contactin associated protein-like 1) [NCBI Gene 53321] {aka Caspr, NCP1, Nrxn4, p190, shm}, Hdac1 (histone deacetylase 1) [NCBI Gene 433759] {aka HD1, Hdac1-ps, MommeD5, RPD3}, MPZ (myelin protein zero) [NCBI Gene 4359] {aka CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3}, Hdac2 (histone deacetylase 2) [NCBI Gene 15182] {aka D10Wsu179e, YAF1, Yy1bp, mRPD3}, Nodal (nodal growth differentiation factor) [NCBI Gene 18119] {aka Tg.413d}, HDAC2 (histone deacetylase 2) [NCBI Gene 3066] {aka HD2, KDAC2, RPD3, YAF1}, HDAC1 (histone deacetylase 1) [NCBI Gene 3065] {aka GON-10, HD1, KDAC1, RPD3, RPD3L1}
- **Diseases:** motor and sensory disturbances (MESH:D014832), peripheral neuropathies (MESH:D010523), CMT (MESH:D002607), demyelination (MESH:D003711)
- **Chemicals:**  (MESH:D015815),  (MESH:C560547),  (MESH:D018993),  (MESH:D009414),  (MESH:C504593),  (MESH:C560546)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC4583451/full.md

## References

1 references — full list in the complete paper: https://tomesphere.com/paper/PMC4583451/full.md

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Source: https://tomesphere.com/paper/PMC4583451