# Integrate and boost: bioscaffolds nurture the cardiac regenerative paradigm

## TL;DR

This paper discusses how bioscaffolds can improve heart regeneration by optimizing stem cell therapies and tissue engineering.

## Contribution

The paper introduces bioscaffolds as a novel approach to enhance cardiac regenerative treatments.

## Key findings

- Traditional stem cell therapies have shown limited clinical success due to methodological and biological challenges.
- Biomaterials and tissue engineering are advancing the next generation of cardiac regenerative strategies.
- Bioscaffolds offer a promising platform for improving the efficacy of heart failure treatments.

## Abstract

The traditional cardiac regenerative paradigm using non-modified adult stem cells with various routes of delivery into the myocardial target has thus far yielded unconvincing clinical outcomes. Besides factors related to heterogeneity in trial methodology, inter-patient variability and the rare incidence of adult stem cells with intrinsic repair potency underscore the importance of further optimization and standardization of regenerative platforms. Cardiac tissue engineering seizing upon the advances of cellular, molecular, and biomaterial development is shaping the next generation of the regenerative paradigm and thereby fostering disruptive curative treatments in heart failure.