# Cross-metathesis reaction of α- and β-vinyl C-glycosides with alkenes

## TL;DR

This paper studies chemical reactions involving sugar derivatives and alkenes, finding optimal conditions for efficient product formation.

## Contribution

A new method for preparing α- and β-vinyl C-deoxyribosides and optimized cross-metathesis conditions are introduced.

## Key findings

- Cross-metathesis of α- and β-vinyl C-deoxyribosides with terminal alkenes in ClCH2CH2Cl yields good results.
- α-vinyl C-galactoside cross-metathesis requires CuI in CH2Cl2 for high product yields.
- A simple preparation method for α- and β-vinyl C-deoxyribosides was developed.

## Abstract

Cross-metathesis of α- and β-vinyl C-deoxyribosides and α-vinyl C-galactoside with various terminal alkenes under different conditions was studied. The cross-metathesis of the former proceeded with good yields of the corresponding products in ClCH2CH2Cl the latter required the presence of CuI in CH2Cl2 to achieve good yields of the products. A simple method for the preparation of α- and β-vinyl C-deoxyribosides was also developed. In addition, feasibility of deprotection and further transformations were briefly explored.