# BF3·Et2O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization

## TL;DR

The paper describes a new method to synthesize a compound that can be used to make SERMs more efficiently.

## Contribution

A novel synthesis of 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one as a SERM precursor with improved yield and fewer steps.

## Key findings

- Anhydrous BF3·Et2O catalyzed reactions were selective for product formation.
- AlCl3, FeCl3, and SnCl4 catalyzed reactions were nonselective.
- The compound was synthesized with a smaller number of steps and good yield.

## Abstract

We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF3·Et2O catalyzed reaction was found to be selective for product formation while anhydrous AlCl3, FeCl3, and SnCl4 catalyzed ones were nonselective.