# Deciphering Crosstalk Circuits in Non-small Cell Lung Cancers with an Increasing Interval Length of Low Dose CT Screening

**Authors:** Rafael Rosell, Niki Karachaliou, Imane Chaib, Sara Pilotto, Emilio Bria, Juan Luis Fernández-Martínez, Jose Luis Ramirez

PMC · DOI: 10.1016/j.ebiom.2015.07.026 · EBioMedicine · 2015-07-21

## Full-text entities

- **Genes:** MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, YBX1 (Y-box binding protein 1) [NCBI Gene 4904] {aka BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, ILK (integrin linked kinase) [NCBI Gene 3611] {aka HEL-S-28, ILK-1, ILK-2, P59, p59ILK}, ITGB1 (integrin subunit beta 1) [NCBI Gene 3688] {aka CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA}, MIR34A (microRNA 34a) [NCBI Gene 407040] {aka MIRN34A, miRNA34A, mir-34, mir-34a}, TWIST1 (twist family bHLH transcription factor 1) [NCBI Gene 7291] {aka ACS3, BPES2, BPES3, CRS, CRS1, CSO}, PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, NOTCH1 (notch receptor 1) [NCBI Gene 4851] {aka AOS5, AOVD1, TAN1, hN1}, SLTM (SAFB like transcription modulator) [NCBI Gene 79811] {aka Met}, HES1 (hes family bHLH transcription factor 1) [NCBI Gene 3280] {aka HES-1, HHL, HRY, bHLHb39}, FOXO1 (forkhead box O1) [NCBI Gene 2308] {aka FKH1, FKHR, FOXO1A}, STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}, PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 5295] {aka AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, GSK3B (glycogen synthase kinase 3 beta) [NCBI Gene 2932], FOXO3 (forkhead box O3) [NCBI Gene 2309] {aka AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A}, ZEB1 (zinc finger E-box binding homeobox 1) [NCBI Gene 6935] {aka AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3}
- **Diseases:** Hypoxia (MESH:D000860), lung cancer (MESH:D008175), lymph node metastases (MESH:D008207), benign pulmonary nodules (MESH:D055613), metastases (MESH:D009362), NSCLC (MESH:D002289), cancer (MESH:D009369), nodules (MESH:D016606), metastatic disease (MESH:D000092182), stage IA disease (MESH:D007676), lung adenocarcinoma (MESH:D000077192)
- **Species:** Homo sapiens (human, species) [taxon 9606], Dipturus trachyderma (ray, species) [taxon 255564]

## Full text

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC4563159/full.md

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Source: https://tomesphere.com/paper/PMC4563159