# Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion

**Authors:** Frédéric Charron

PMC · DOI: 10.1371/journal.pgen.1005441 · PLoS Genetics · 2015-09-03

## Full-text entities

- **Genes:** robo3 (roundabout 3) [NCBI Gene 33314] {aka CG14345, CG5423, CT17158, Dmel\CG5423, Robo, Robo 3}, robo1 (roundabout 1) [NCBI Gene 37603] {aka BEST:GM07780, CG13521, CT32892, D-Robo1, Dmel\CG13521, ROBO}, rab (rabbit) [NCBI Gene 252473], ena (enabled) [NCBI Gene 37201] {aka CG15112, Dmel\CG15112, ENA/VASP, Enabled, Enb, VASP}, AP-2alpha (Adaptor Protein complex 2, alpha subunit) [NCBI Gene 33211] {aka AP-2, AP2, AP2alpha, Ada, Alpha-Adaptin, CG31654}, fra (frazzled) [NCBI Gene 36377] {aka CG8581, CT24981, DCC, Dcc, Dmel\CG8581, fra/DCC}, ROBO2 (roundabout guidance receptor 2) [NCBI Gene 6092] {aka SAX3}, RhoGEF64C (Rho guanine nucleotide exchange factor at 64C) [NCBI Gene 38578] {aka CG13709, CG13710, CG32239, Dmel\CG32239, EP(3)3035, EP3035}, Pak (p21-activated kinase) [NCBI Gene 44039] {aka CG10295, D-Pak, DPAK, DPak, DPak1, DmPAK1}, dock (dreadlocks) [NCBI Gene 33262] {aka 2L19, CG3727, Dm0447, Dmel\CG3727, Nck, dck}, ROBO3 (roundabout guidance receptor 3) [NCBI Gene 64221] {aka HGPPS, HGPPS1, HGPS, RBIG1, RIG1}, robo2 (roundabout 2) [NCBI Gene 44522] {aka CG14347, CG14348, CG5481, CG5574, CT17326, D-Robo2}, shi (shibire) [NCBI Gene 45928] {aka CG18102, DNM3, DYN, Ddyn, Ddyn3, Ddyn4}, Clc (Clathrin light chain) [NCBI Gene 40221] {aka CG6948, Dmel\CG6948, clc1}, Sos (Son of sevenless) [NCBI Gene 34790] {aka 2.3, 34Ea, BG:DS00941.4, CG7793, Dmel\CG7793, E(sev)2A}, Rab5 (Rab5) [NCBI Gene 33418] {aka AAF51265, BAA88244, CG3664, DRab5, Dm Rab5, DmRab5}, ROBO1 (roundabout guidance receptor 1) [NCBI Gene 6091] {aka CPHD8, DUTT1, NORS, NYS8, SAX3}, Rab7 (Rab7) [NCBI Gene 42841] {aka AAF56218, CG5915, DRAB7, DRab7, Dm Rab7, DmRab7}, EndoA (Endophilin A) [NCBI Gene 42265] {aka CG14296, D-endo, D-endoA, Dendo-A, Dmel\CG14296, Endo}, ROBO4 (roundabout guidance receptor 4) [NCBI Gene 54538] {aka AOVD3, ECSM4, MRB}
- **Diseases:** HGPPS (MESH:C564593), schizophrenia (MESH:D012559), autism (MESH:D001321), dyslexia (MESH:D004410)
- **Chemicals:** Slit (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Drosophila melanogaster (fruit fly, species) [taxon 7227], Xenopus laevis (African clawed frog, species) [taxon 8355]

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC4559454/full.md

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Source: https://tomesphere.com/paper/PMC4559454