# Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk

## TL;DR

This study shows that Plantago ovata husk fiber may protect the intestinal lining from damage caused by aspirin-like drugs.

## Contribution

The novel finding is that Plantago ovata husk significantly reduces aspirin-induced intestinal damage in rabbits.

## Key findings

- Plantago ovata husk reduced duodenal lesions caused by acetylsalicylic acid in rabbits.
- The protective effect was more pronounced with longer treatment durations (28 days vs. 14 days).
- Treated animals showed normal duodenal structure similar to control animals.

## Abstract

Several studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa. The aim of this study was to evaluate the protective action of the soluble fiber Plantago ovata husk against intestinal damage.

To evaluate the anti-ulcerogenic effect on duodenal mucosa of the soluble fiber Plantago ovata husk, low-dose acetylsalicylic acid (10 mg/kg) was given orally to animals once daily for 14 or 28 days with and without Plantago ovata husk (100 mg/kg). 24 h after final dosing duodenal samples were removed for anatomopathological evaluation. Villi were examined by both light and scanning electron microscopy.

Acetylsalicylic acid induced severe lesions in duodenal mucosa of rabbits, including erosions, epithelium disorganization, and cell vacuolization, increasing as well the amount of mononuclear and caliciform cells. Damage was much more severe in animals treated for 28 days. In groups receiving Plantago ovata husk, a significant attenuation of acetylsalicylic acid-induced lesions was already observed in group treated for 14 days, becoming more evident in those treated for 28 days, all of them with duodenal cytoarchitecture normal and similar to control animals.

These findings suggest that Plantago ovata husk may protect intestinal mucosa probably by limiting acetylsalicylic acid penetration into epithelial cells, although further studies are needed to confirm the same effect in other experimental models of induced mucosal damage and to elucidate the mechanisms of fiber protection.