RECIST Applied to Realistic Tumor Models
Zachary H. Levine, Benjamin R. Galloway, Adele P. Peskin
TL;DR
This paper evaluates how well RECIST, a tumor size measurement method, works for realistic tumor shapes compared to simple ellipsoids.
Contribution
The novelty is analyzing RECIST accuracy using geometric models of realistic tumors made of ellipsoids.
Findings
RECIST is less accurate for realistic tumor models than for ellipsoids.
Tumor shape complexity affects the reliability of RECIST volume predictions.
Abstract
RECIST (Response Evaluation Criteria in Solid Tumors) is a linear measure intended to predict tumor size in medical computed tomography (CT). In this work, using purely geometrical considerations, we estimate how well RECIST can predict the volume of randomly-oriented tumor models, each composed of the union of ellipsoids. The principal conclusion is that RECIST is likely to work less well for realistic tumors than for ellipsoids.
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Taxonomy
TopicsNuclear and radioactivity studies