# Interaction between Flavivirus and Cytoskeleton during Virus Replication

## TL;DR

This review explores how Flaviviruses interact with the host cell's cytoskeleton to support their replication process.

## Contribution

The paper provides a comprehensive overview of the role of the cytoskeleton in Flavivirus replication mechanisms.

## Key findings

- Flaviviruses interact with host cell cytoskeletons to form replication sites.
- Cytoskeletal components like actin and microtubules are involved in viral entry and transport.
- The cytoskeleton supports scaffold assembly and virus egress during infection.

## Abstract

Flaviviruses are potentially human pathogens that cause major epidemics worldwide. Flavivirus interacts with host cell factors to form a favourable virus replication site. Cell cytoskeletons have been observed to have close contact with flaviviruses, which expands the understanding of cytoskeleton functions during virus replication, although many detailed mechanisms are still unclear. The interactions between the virus and host cytoskeletons such as actin filaments, microtubules, and intermediate filaments have provided insight into molecular alterations during the virus infection, such as viral entry, in-cell transport, scaffold assembly, and egress. This review article focuses on the utilization of cytoskeleton by Flavivirus and the respective functions during virus replication.