# Obscure Severe Infrarenal Aortoiliac Stenosis With Severe Transient Lactic Acidosis

**Authors:** Teerapat Nantsupawat, Charoen Mankongpaisarnrung, Suthipong Soontrapa, Chok Limsuwat, Kenneth Nugent

PMC · DOI: 10.1177/2324709613479940 · 2013-01-01

## TL;DR

A rare case shows that severe leg pain and lactic acidosis can be signs of a dangerous aortic blockage, highlighting the need for quick vascular testing.

## Contribution

Highlights an unusual presentation of infrarenal aortoiliac stenosis with transient lactic acidosis and leg pain.

## Key findings

- Severe lactic acidosis and leg pain can indicate infrarenal aortoiliac stenosis.
- Computed tomography confirmed infrarenal aortoiliac thrombosis in the patient.
- Vascular studies are crucial for timely diagnosis of this condition.

## Abstract

A 57-year-old man presented with sudden onset of leg pain, right-sided weakness, aphasia, confusion, drooling, and severe lactic acidosis (15 mmol/L). He had normal peripheral pulses and demonstrated no pain, pallor, poikilothermia, paresthesia, or paralysis. Empiric antibiotics, aspirin, full-dose enoxaparin, and intravenous fluid were initiated. Lactic acid level decreased to 2.5 mmol/L. The patient was subsequently extubated and was alert and oriented with no complaints of leg or abdominal pain. Unexpectedly, the patient developed cardiac arrest, rebound severe lactic acidosis (8.13 mmol/L), and signs of acute limb ischemia. Emergent computed tomography of the aorta confirmed infrarenal aortoiliac thrombosis. Transient leg pain and transient severe lactic acidosis can be unusual presentations of severe infrarenal aortoiliac stenosis. When in doubt, vascular studies should be implemented without delay to identify this catastrophic diagnosis.

## Linked entities

- **Diseases:** lactic acidosis (MONDO:0006040)

## Full-text entities

- **Genes:** MB (myoglobin) [NCBI Gene 4151] {aka MYOSB, PVALB}, HBG2 (hemoglobin subunit gamma 2) [NCBI Gene 3048] {aka HBG-T1, TNCY}
- **Diseases:** acute coronary syndrome (MESH:D054058), hypoxic hepatitis (MESH:D002534), intracranial hemorrhage (MESH:D020300), hepatitis (MESH:D056486), aphasia (MESH:D001037), paresthesia (MESH:D010292), Grand mal seizures (MESH:D004830), metabolic acidosis (MESH:D000138), pneumonia (MESH:D011014), leg weakness (MESH:D018908), malignancy (MESH:D009369), pulmonary emboli (MESH:D020766), left limb gangrene (MESH:D005734), aortic dissection (MESH:D000784), aortic stenosis (MESH:D001024), renal, pulmonary, liver, and cardiac complications (MESH:D008107), aortic occlusion (MESH:D001157), viral hepatitis (MESH:D014777), sepsis (MESH:D018805), Aortoiliac Stenosis (MESH:D003251), leg pain (MESH:D010146), Reperfusion injury (MESH:D015427), Livedo reticularis (MESH:D054068), aortic thrombosis (MESH:D013927), multi-organ dysfunction (MESH:D009102), Acute tubular necrosis (MESH:D007683), hepatic failure (MESH:D017093), congestive heart failure (MESH:D006333), hip fracture (MESH:D006620), renal failure (MESH:D051437), inborn errors of metabolism (MESH:D008661), iliac artery (MESH:D017543), hypercoagulability (MESH:D019851), pleural effusion (MESH:D010996), rhabdomyolysis (MESH:D012206), ischemic (MESH:D002545), inflammatory (MESH:D007249), alcoholic intoxication (MESH:D000435), acute kidney injury (MESH:D058186), hypertension (MESH:D006973), confusion (MESH:D003221), PR (MESH:D008151), HIV (MESH:D015658), aortic trauma (MESH:D014947), arteriosclerosis (MESH:D001161), hypoxic ischemic hepatitis (MESH:D020925), asystole (MESH:D006323), abdominal aortic occlusion (MESH:D017544), nephropathy (MESH:D007674), depressed (MESH:D003866), basal ganglion infarct (MESH:D007238), cerebrovascular accident (MESH:D020521), paralysis (MESH:D010243), depressed left ventricular function (MESH:D018487), Bowel ischemia (MESH:D007511), drooling (MESH:D012798), hypoxia (MESH:D000860), pericardial rub (MESH:D012135), fatty infiltration (MESH:D017254), MR (MESH:D008944)
- **Chemicals:** potassium (MESH:D011188), levofloxacin (MESH:D064704), glucose (MESH:D005947), urea (MESH:D014508), Lactic acid (MESH:D019344), sorbitol (MESH:D013012), HCO3 (MESH:D001639), metformin (MESH:D008687), chloride (MESH:D002712), kayexalate (MESH:C003321), sodium bicarbonate (MESH:D017693), piperacillin-tazobactam (MESH:D000077725), creatinine (MESH:D003404), vancomycin (MESH:D014640), acetone (MESH:D000096), oxygen (MESH:D010100), enoxaparin (MESH:D017984), Aspirin (MESH:D001241), insulin (MESH:D007328), PCO2 (-), calcium gluconate (MESH:D002125), propofol (MESH:D015742), heparin (MESH:D006493), bilirubin (MESH:D001663), PO2 (MESH:C093415), pyruvate (MESH:D019289), ethanol (MESH:D000431), sodium (MESH:D012964)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4528787/full.md

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Source: https://tomesphere.com/paper/PMC4528787