# A 28-Year-Old Woman with Fever, Weight Loss, Pancytopenia, and Multiple Hepatosplenic and Bone Lesions

**Authors:** Fereshte Sheybani, Bezat Amiri, HamidReza Naderi, Mohammad Reza Sarvghad

PMC · DOI: 10.1155/2015/759856 · Case Reports in Infectious Diseases · 2015-07-13

## TL;DR

This paper describes a rare case of acute brucellosis in a 28-year-old woman with fever, weight loss, and multiple organ lesions.

## Contribution

The novelty lies in the rare presentation of brucellosis involving multifocal osteomyelitis and hepatosplenic lesions.

## Key findings

- Brucellosis can present with multifocal osteomyelitis and hepatosplenic lesions.
- The case highlights the importance of considering brucellosis in febrile illnesses with compatible epidemiology.
- Systemic zoonotic infections like brucellosis can affect multiple organs simultaneously.

## Abstract

Brucellosis is a systemic zoonotic infection that can involve any organ or system in the body. It may present with a broad spectrum of clinical manifestations. Considering such myriad presentations, brucellosis should always be considered in the differential diagnosis of any febrile illness in a compatible epidemiological context. Here, we report a rare presentation of acute brucellosis with multifocal osteomyelitis and hepatosplenic lesions.

## Linked entities

- **Diseases:** brucellosis (MONDO:0005683)

## Full-text entities

- **Genes:** GGT1 (gamma-glutamyltransferase 1) [NCBI Gene 2678] {aka CD224, D22S672, D22S732, GGT, GGT 1, GGTD}
- **Diseases:** osteolytic lesions (MESH:D030981), hemophagocytic syndrome (MESH:D051359), zoonotic infection (MESH:D015047), involvement (MESH:C564676), splenic infarction (MESH:D013159), mucocutaneous lesions (MESH:D007897), Hepatosplenic and Bone Lesions (MESH:D001847), cardiac (MESH:D006331), lymphoproliferative disease (MESH:D008232), sweats (MESH:D013543), depressed mood (MESH:D003866), chills (MESH:D023341), spondylitis (MESH:D013166), arthritis (MESH:D001168), Pancytopenia (MESH:D010198), splenic rupture (MESH:D013161), infection (MESH:D007239), bursitis (MESH:D002062), Fever (MESH:D005334), hepatosplenic lesions (MESH:D009059), hepatosplenomegaly (MESH:C535727), Osteoarticular involvement (MESH:D014394), granuloma (MESH:D006099), Chronic hepatic and splenic involvement (MESH:D006521), psychomotor retardation (MESH:D011596), abscess formation (MESH:D058426), adenopathies (MESH:D000072281), cardiac murmurs (MESH:D006337), abscesses of the liver and spleen (MESH:D008100), splenomegaly (MESH:D013163), Weight Loss (MESH:D015431), Brucellosis (MESH:D002006), bacteremia (MESH:D016470), hematoma (MESH:D006406), tumor lesion (MESH:D009369), abscesses (MESH:D000038), vomiting (MESH:D014839), nausea (MESH:D009325), hepatomegaly (MESH:D006529), brucellar osteomyelitis (MESH:D010019), metastatic carcinoma (MESH:C538445), para-aortic lymphadenopathies (MESH:D008206), anorexia (MESH:D000855), Sacroiliitis (MESH:D058566), calcification (MESH:D002114), tenosynovitis (MESH:D013717)
- **Species:** Brucella melitensis (species) [taxon 29459], hepatitis C [taxon 11103], Human immunodeficiency virus (species) [taxon 12721], Homo sapiens (human, species) [taxon 9606], Brucella (genus) [taxon 234]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4515516/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC4515516/full.md

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Source: https://tomesphere.com/paper/PMC4515516