# Umbilical Cord Tissue-Derived Cells as Therapeutic Agents **Authors:** Olga Maslova, Miroslav Novak, Peter Kruzliak PMC · DOI: 10.1155/2015/150609 · Stem Cells International · 2015-07-12 ## TL;DR This review discusses the potential of umbilical cord-derived cells as therapeutic agents and addresses challenges in their clinical use. ## Contribution The paper highlights the advantages and controversies of using umbilical cord-derived cells in clinical settings. ## Key findings - UC-derived cells have advantages over other stem cell sources. - Adapting cell isolation and culturing methods to GMP standards is necessary. - Future perspectives for UC-derived cells include improved cryopreservation techniques. ## Abstract Although the characteristics of SC, including UC-derived cells, are a dramatically discussed issue, this review will focus particularly on some controversial issues regarding clinical utility of cells isolated from UC tissue. UC-derived cells have several advantages compared to other types and sources of stem cells. The impact of UC topography on cell characteristics is briefly discussed. The necessity to adapt existing methods of cell isolation and culturing to GMP conditions is mentioned, as well as possible cryopreservation of this material. Light is shed on some future perspectives for UC-derived cells. ## Full-text entities - **Genes:** DCN (decorin) [NCBI Gene 1634] {aka CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B}, CXCL2 (C-X-C motif chemokine ligand 2) [NCBI Gene 2920] {aka CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2}, CXCL5 (C-X-C motif chemokine ligand 5) [NCBI Gene 6374] {aka ENA-78, SCYB5}, RB1 (RB transcriptional corepressor 1) [NCBI Gene 5925] {aka OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb}, HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, CD34 (CD34 molecule) [NCBI Gene 947], TGFB2 (transforming growth factor beta 2) [NCBI Gene 7042] {aka CAEND2, G-TSF, LDS4, TGF-beta2}, SERPINE1 (serpin family E member 1) [NCBI Gene 5054] {aka PAI, PAI-1, PAI1, PLANH1}, POU5F1 (POU class 5 homeobox 1) [NCBI Gene 5460] {aka OCT3, OCT4, OCT4Borf1, OTF-3, OTF3, OTF4}, CCN2 (cellular communication network factor 2) [NCBI Gene 1490] {aka CTGF, HCS24, IBP-8, IGFBP8, KMD, NOV2}, THY1 (Thy-1 cell surface antigen) [NCBI Gene 7070] {aka CD90, CDw90}, MET (MET proto-oncogene, receptor tyrosine kinase) [NCBI Gene 4233] {aka AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}, TGFB3 (transforming growth factor beta 3) [NCBI Gene 7043] {aka ARVD, ARVD1, LDS5, RNHF, TGF-beta3}, HBEGF (heparin binding EGF like growth factor) [NCBI Gene 1839] {aka DTR, DTS, DTSF, HEGFL}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, FGF2 (fibroblast growth factor 2) [NCBI Gene 2247] {aka BFGF, FGF-2, FGFB, HBGF-2}, MDK (midkine) [NCBI Gene 4192] {aka ARAP, MK, NEGF2}, NTF3 (neurotrophin 3) [NCBI Gene 4908] {aka HDNF, NGF-2, NGF2, NT-3, NT3}, FGF9 (fibroblast growth factor 9) [NCBI Gene 2254] {aka FGF-9, GAF, HBFG-9, HBGF-9, SYNS3}, NT5E (5'-nucleotidase ecto) [NCBI Gene 4907] {aka CALJA, CD73, E5NT, NT, NT5, NTE}, HGF (hepatocyte growth factor) [NCBI Gene 3082] {aka DFNB39, F-TCF, HGFB, HPTA, SF} - **Diseases:** liver cirrhosis (MESH:D008103), liver disease (MESH:D008107), muscle (MESH:D019042), malignancies (MESH:D009369), rheumatoid arthritis (MESH:D001172), perinatal disorders of the central nervous system (MESH:D002493), spinal cord injury (MESH:D013119), autoimmune diseases (MESH:D001327), Cartilage (MESH:D002357), inflammation (MESH:D007249), calcification (MESH:D002114), cardiovascular diseases (MESH:D002318), allergies (MESH:D004342), graft versus host disease (MESH:D006086), infections (MESH:D007239), teratoma (MESH:D013724), osteoarthritis (MESH:D010003) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Cell lines:** WJ — Homo sapiens (Human), Glioblastoma, Cancer cell line (CVCL_W352), MSC — Homo sapiens (Human), Somatic stem cell (CVCL_WG60) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC4515303/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC4515303/full.md ## References 119 references — full list in the complete paper: https://tomesphere.com/paper/PMC4515303/full.md --- Source: https://tomesphere.com/paper/PMC4515303